CryoEM structure of monoclonal Fab 045-09 2B05 binding the lateral patch of influenza virus H1 HA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mem
Q-score: 0.425
Guthmiller JJ, Han J, Li L, Freyn AW, Liu STH, Stovicek O, Stamper CT, Dugan HL, Tepora ME, Utset HA, Bitar DJ, Hamel NJ, Changrob S, Zheng NY, Huang M, Krammer F, Nachbagauer R, Palese P, Ward AB, Wilson PC
Sci Transl Med (2021) 13 [ Pubmed: 34078743 DOI: doi:10.1126/scitranslmed.abg4535 ]
- Light chain of monoclonal antibody 045-09 2b05 (11 kDa, Protein from Homo sapiens)
- Cryoem structure of monoclonal fab 045-09 2b05 binding the lateral patch of h1 ha (Complex)
- Hemagglutinin (Complex from Influenza A virus (strain swl A/California/04/2009 H1N1))
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus (strain swl A/California/04/2009 H1N1))
- Hemagglutinin ha2 chain (19 kDa, Protein from Influenza A virus (strain swl A/California/04/2009 H1N1))
- Monoclonal fab 045-09 2b05 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of monoclonal antibody 045-09 2b05 (12 kDa, Protein from Homo sapiens)
Negative stain map of monoclonal Fab 23 binding the lateral patch of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]
Negative stain map of monoclonal Fab 45 binding the esterase domain of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]
Negative stain map of monoclonal Fab 50 binding the lateral patch of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]
Negative stain map of monoclonal Fab 56 binding the lateral patch of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]
Negative stain map of monoclonal Fab 68 binding the Sa antigenic site of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]
Negative stain map of monoclonal Fab 76 binding the stem of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]
CryoEM map of monoclonal Fabs 45 and 56 binding the esterase and lateral patch of H1 HA
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2018102118 Pubmed: 33593910 ]