ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

Clin Gastroenterol Hepatol. 2020 Aug;18(9):2128-2130.e2. doi: 10.1016/j.cgh.2020.04.040. Epub 2020 Apr 22.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) in human beings, has caused a serious public health issue.1 Attention to pancreatic injury is lacking, which may impact patients' prognosis. In this study, we explored the expression and distribution of angiotensin-converting enzyme 2 (ACE2), the receptor of SARS-CoV-2, in the pancreas. Combined with clinical data, we showed that pancreatic injury can occur in some COVID-19 patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus / growth & development*
  • COVID-19
  • Coronavirus Infections / complications*
  • Female
  • Gene Expression Profiling*
  • Humans
  • Male
  • Middle Aged
  • Pancreas / enzymology*
  • Pancreatic Diseases / physiopathology*
  • Pandemics
  • Peptidyl-Dipeptidase A / analysis*
  • Pneumonia, Viral / complications*
  • Receptors, Virus / analysis*
  • SARS-CoV-2
  • Young Adult

Substances

  • Receptors, Virus
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2