 Gene Therapy RECENT COVERAGE
Getting the Athletic Edge May Mean Altering Genes
By JERE LONGMAN
(May 11, 2001) Concerned that athletes will soon employ genetic engineering to enhance performance, the I.O.C. and the affiliated World Anti-Doping Agency are about to convene inaugural meetings on the subject. Gene Therapy Is Performed in Bid to Halt Alzheimer's
By SANDRA BLAKESLEE
(April 11, 2001) Researchers injected modified cells into the brain of an Alzheimer's patient, the first time gene therapy had been used to prevent cell loss in the syndrome. When Gene Sequencing Becomes a Fact of Life
By ANDREW POLLACK
(January 17, 2001) Visible Genetics has developed a test to sequence genes of the virus that causes AIDS, providing information to help doctors choose which of the 15 or so available drugs will work best against a particular patient's infection.  Monkey Born With Genetically Engineered Cells
By GINA KOLATA
(January 12, 2001) Scientists in Portland, Ore., report that they have inserted a foreign gene into a monkey egg, fertilized the egg and produced a baby monkey with the added gene in its cells.
Genetic Studies Promise a Path to Better Treatment of Addictions
By LINDA CARROLL
(November 14, 2000) Researchers have devised a paradigm that may help explain why some people get hooked after a single "taste" of an illegal drug while others can use it for years and quit when they choose. Teaching the Body to Heal Itself
By NICHOLAS WADE
(November 7, 2000) With the new tools of genomics and stem cell biology, some biologists hope to develop a set of novel treatments. "Regenerative medicine," as some call it, would depend on the same agents the body itself uses to repair its own fabric. Newfound Protein Touches Off Race for New Therapies
By NICHOLAS WADE
(October 31, 2000) A long-elusive protein that could have a serious impact in medicine has recently come to light because of the availability of the human genome sequence. Genetic Clues on Failures of Pregnancies
By THE ASSOCIATED PRESS
(October 24, 2000) Most human embryos possess genetic defects just days into their development, a finding that researchers say may explain why many pregnancies fail shortly after conception. Baby Conceived to Provide Cell Transplant for His Dying Sister
By DENISE GRADY
(October 4, 2000) For the first time, genetic tests have been used to help parents have a baby with the exact traits needed to provide a cell transplant to treat a desperately ill sibling. Researchers Find Gene for Type 2 Diabetes
By NICHOLAS WADE
(September 26, 2000) A novel gene associated with development of Type 2, or adult-onset, diabetes, a major and growing public health problem, has been identified from study of Mexican-Americans in Starr County, Tex., a population with an unusually heavy burden of the disease. Dr. Leonard Guarente: Searching for Genes to Slow the Hands of Biological Time
By NICHOLAS WADE
(September 26, 2000) Dr. Leonard Guarente, a professor of biology at the Massachusetts Institute of Technology, studies the genes that control aging, and has recently been enjoying a string of successes in a long intractable field of research. Company Seeking Donors of DNA for a 'Gene Trust'
By ANDREW POLLACK
(August 1, 2000) DNA Sciences will open a Web site on Tuesday to recruit people to donate DNA to help find genes that cause disease. DNA Innovation Lets Team Undermine the AIDS Virus
By NICHOLAS WADE
(July 21, 2000) Biologists at the University of Texas have invented a novel and apparently far-reaching method of singling out precise regions of DNA. Outgrowth of Landmark Framingham Study
By GINA KOLATA
(June 17, 2000) In what some call a taste of the future of genetic medicine, Boston University has created a company to analyze a valuable cache of medical data from a federally financed study that has lasted 52 years. Despite Ferment, Gene Therapy Progresses
By SHERYL GAY STOLBERG
(June 6, 2000) While politicians and the press have spent the year focusing on accusations of lax government oversight and shoddily run clinical trials, the science of gene therapy has been making quiet, steady progress. Institute Restricted After Gene Therapy Death
By SHERYL GAY STOLBERG
(May 4, 2000) The scientist who ran a gene therapy study that killed an 18-year-old patient at the University of Pennsylvania will no longer conduct experiments on people, and the prestigious gene therapy institute he founded is being scaled back, university officials announced today. Fines Proposed for Violations of Human Research Rules
By SHERYL GAY STOLBERG
(May 24, 2000) Responding to widely publicized lapses in medical experiments, the Clinton administration announced today that it would seek authority from Congress to levy fines of up to $250,000 on scientists who violate federal rules for human research and $1 million on the universities that employ them. A Second Death Linked to Gene Therapy
By PHILIP J. HILTS
(May 4, 2000) Researchers at St. Elizabeth's Medical Center here failed to report the death of a patient in gene therapy experiments and might have contributed to the growth of cancer in another patient, whose condition was also reported improperly, investigators for the Food and Drug Administration have said. In a First, Gene Therapy Saves Lives of Infants
By GINA KOLATA
(April 28, 2000) For the first time, gene therapy has unequivocally succeeded, scientists say. Doctor used the treatment, which involves adding working genes to cells, to save the lives of several infants who might otherwise have died of a severe immune disorder. From Mutated Fish, Clues to Human Ills
By CAREY GOLDBERG
(March 28, 2000) In the race to identify genes that typify the dawning genomics era, Dr. Nancy Hopkins' lab has developed a technique that uses retroviruses to induce mutations of single genes in zebra fish. The technique allows for quick isolation and cloning. Hint of Success Indicated in Gene Therapy
By NICHOLAS WADE
(March 3, 2000) Gene therapy, a technique long on promise and so far very short on fulfillment, may be achieving a glimmering of success in a treatment for hemophilia B, a disease in which the blood does not clot properly. Scientists Defend Suspended Gene Therapy
By SHERYL GAY STOLBERG
(February 15, 2000) In a vigorous defense of their suspended gene therapy program, officials at the University of Pennsylvania said that while there were administrative lapses, they did not in any way contribute to the death of an 18-year-old patient. Gene Therapy Might Have Exposed 20 Children to Lethal Viruses
By SHERYL GAY STOLBERG
(February 11, 2000) As many as 20 children with brain cancer may have been accidentally exposed to the viruses that cause AIDS and hepatitis C during a gene therapy experiment at hospitals in Houston and Memphis, a Clinton administration official said. Hospital in Boston Halts Gene Therapy Research
By PHILIP J. HILTS
(February 8, 2000) Beth Israel Deaconess Medical Center in Boston has temporarily suspended a gene therapy experiment to permit further discussion of the issues underlying such work after a young man's death last year in a similar trial in Pennsylvania. Senators Press for Answers on Gene Therapy
By SHERYL GAY STOLBERG
(February 3, 2000) Under pressure from Congress to explain lapses in oversight of gene therapy, federal health officials acknowledged that they could not be certain whether experiments had hastened, or possibly caused, the deaths of patients other than the 18-year-old man who died at the University of Pennsylvania last fall. Agency Failed to Monitor Patients in Gene Research
By SHERYL GAY STOLBERG
(February 2, 2000) Officials at the National Institutes of Health said that they had failed to keep track of how patients fared during gene therapy experiments and had outlined steps to ensure that scientists followed rules requiring them to report information about harmful side effects. Youth's Death Shakes New Field of Gene Experiments on Humans
By SHERYL GAY STOLBERG
(January 27, 2000) Perhaps no event in recent medical history has done more to shine light on the inherent conflict of interest between researchers and their subjects than the death of an 18-year-old from Tucson in a gene therapy experiment at the University of Pennsylvania. Tribute and Apologies in Gene Therapy Death
By SHERYL GAY STOLBERG
(December 10, 1999) Three months ago, a man's 18-year-old son became the first person killed by gene therapy. Thursday, that man addressed the scientists who had gathered this week to examine the experiment that cost his son his life. F.D.A. Officials Fault Penn Team in Gene Therapy Death
By SHERYL GAY STOLBERG
(December 9, 1999) Officials of the Food and Drug Administration said Wednesday that Jesse Gelsinger, the 18-year-old Arizona man who lost his life in a gene therapy experiment in September, was ineligible for the clinical trial and should not have been treated. Successful Gene Therapy on Hemophilia and Heart Cells Reported
By LAWRENCE M. FISHER
(December 7, 1999) Doctors have successfully used gene therapy to treat a form of hemophilia, they reported on Monday, injecting patients with a gene that produced a blood-clotting protein without adverse side effects. A Death Puts Gene Therapy Under Increasing Scrutiny
By SHERYL GAY STOLBERG
(November 4, 1999) Six weeks after an 18-year-old Arizona man died unexpectedly in a gene therapy experiment, the field's safety record is coming under increasing scrutiny, and new information is coming to light about patients who may have been harmed in other clinical trials. • Patient's Death Stops Gene Therapy Studies (October 12, 1999)
• Patient Dies While Undergoing Gene Therapy (September 29, 1999)
• At Gene Therapy's Frontier, the Amish Build a Clinic (June 29, 1999)
• Gene Therapy Passes Important Test, in Monkeys (February 23, 1999)
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