Edited By: SHOU-JIANG (SJ) GAO
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Novel Coronavirus (COVID-19) Special Issues
Read the Journal of Medical Virology's three special issues on the Novel Coronavirus (COVID-19). All articles are currently free to access.
Top Associate Editors and Reviewers in 2023
Click here to see a list of our top Associate Editors, who handled more than 50 manuscripts for the Journal of Medical Virology in 2023, and a list of our top Reviewers, who reviewed more than 15 manuscripts for the journal.
Call for Papers: Reflecting on 30 Years of Discovery: Kaposi's-Sarcoma Associated Herpesvirus (KSHV) - Advances, Insights, and Prospects
On the 30th anniversary of the discovery of KSHV, The Journal of Medical Virology (JMV) invites manuscript submissions for a Special Issue dedicated to exploring the latest advancements and emerging topics in the field. This collection, comprising original research, reviews, Letters to the Editor, and Commentaries, aims to provide a comprehensive overview of key aspects of KSHV and its associated malignancies. Please see here for further details. Submissions are requested by December 31st, 2024.
Novel Coronavirus Outbreak
Wiley is making collections of journal articles and book chapters on the current Novel Coronavirus Outbreak freely available to the global scientific community, including many articles from the Journal of Medical Virology. View the collections on our microsite.
Articles
Poor durability of the neutralizing response against XBB sublineages after a bivalent mRNA COVID‐19 booster dose in persons with HIV
-  16 April 2024
HBV PreC interacts with SUV39H1 to induce viral replication by blocking the proteasomal degradation of viral polymerase
-  16 April 2024
Naturally developed HPV16 antibodies and risk of newly detected cervical HPV infection outcomes
-  16 April 2024
Remarkable increase in the detection and molecular characterization of adenovirus F41 in children with acute gastroenteritis in Japan, 2017–2023
-  16 April 2024
Incidence of fatigue 2 years after SARS‐CoV‐2 infection: An updated meta‐analysis and subgroup analysis
-  16 April 2024
A peptide derived from SARS‐CoV‐2 nucleocapsid protein with broad‐spectrum anti‐coronavirus activity
Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level
Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses during viral latency in B lymphocytes
Th2 and Th17‐associated immunopathology following SARS‐CoV‐2 breakthrough infection in Spike‐vaccinated ACE2‐humanized mice
MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies
Persistent steatosis correlates with decreased fibrosis regression during anti‐HBV treatment in patients with chronic HBV infection
IL‐21 collaborates with anti‐TIGIT to restore NK cell function in chronic HBV infection
Humoral and cellular immune responses in fully vaccinated individuals with or without SARS‐CoV‐2 breakthrough infection: Results from the CoV‐ADAPT cohort
Associations between COVID‐19 therapies and inpatient gastrointestinal bleeding: A multisite retrospective study
SARS‐CoV‐2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction
Lipid nanoparticle‐mediated delivery of IL‐21‐encoding mRNA induces viral clearance in mouse models of hepatitis B virus persistence
Molecular and immune signatures, and pathological trajectories of fatal COVID‐19 lungs defined by in situ spatial single‐cell transcriptome analysis
Postpandemic rebound of adeno‐associated virus type 2 (AAV2) infections temporally associated with an outbreak of unexplained severe acute hepatitis in children in the United Kingdom
Persistent hepatitis B virus and HIV coinfections in dually humanized mice engrafted with human liver and immune system
Dynamics of parainfluenza virus among hospitalized children with acute respiratory tract infection under two‐child policy and COVID‐19 pandemic in Hubei Province, China, 2014–2022
Spatial tissue proteomics reveals distinct landscapes of heterogeneity in cutaneous papillomavirus‐induced keratinocyte carcinomas
Trends and disparities in 44 national notifiable infectious diseases in China: An analysis of national surveillance data from 2010 to 2019
In vitro and in vivo suppression of SARS‐CoV‐2 replication by a modified, short, cell‐penetrating peptide targeting the C‐terminal domain of the viral spike protein
SARS‐CoV‐2 infection of kidney tissues from severe COVID‐19 patients
Surveillance, isolation and genomic characterization of Pteropine orthoreovirus of probable bat origin among patients with acute respiratory infection in Malaysia
Phosphorylation of enteroviral 2Apro at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis
Avian influenza A virus H7N9 in China, a role reversal from reassortment receptor to the donator
Gimap5 promoted RSV degradation through interaction with M6PR
Highlights
RSV infection downregulated the expression of Gimap5 and M6PR.
Gimap5 accelerated the degradation of RSV and its receptor IGF–1R in lysosome.
Gimap5 agonists Z27, Z84, Z61 can effectively reduce RSV infection and RSV–induced complications in vivo and in vitro.
Comparative analysis of SARS‐CoV‐2 Omicron BA.2.12.1 and BA.5.2 variants
Infection phase‐dependent dynamics of the viral and host N6‐methyladenosine epitranscriptome in the lifecycle of an oncogenic virus in vivo
Broadly neutralizing antibodies recognizing different antigenic epitopes act synergistically against the influenza B virus
Production of single‐cycle infectious SARS‐CoV‐2 through a trans‐complemented replicon
- Journal of Medical Virology
-  6078-6090
-  10.1002/jmv.28057
Single‐cell transcriptomic atlas reveals distinct immunological responses between COVID‐19 vaccine and natural SARS‐CoV‐2 infection
- Journal of Medical Virology
-  5304-5324
-  10.1002/jmv.28012
Cell‐to‐cell transmission of HIV‐1 from provirus‐activated cells to resting naïve and memory human primary CD4 T cells is highly efficient and requires CD4 and F‐actin but not chemokine receptors
- Journal of Medical Virology
-  5434-5450
-  10.1002/jmv.28005
Importance
HIV-1 eradication from infected individuals remains a major medical challenge. Combination antiretroviral therapy (ART) has led to a profound reduction in HIV-1-related morbidity and mortality. However, ART fails to eliminate HIV-1, as patients on ART still have residual viremia. The persistent viremia mainly arises from replication-competent proviruses in long-lived latently infected cells, which represent a major obstacle for HIV-1 eradication. One major effort to purge these latently infected cells has focused on developing the “shock and kill” approach for forcing provirus reactivation to induce cell killing. The “shock and kill” approach must be used with ART to prevent new infections. We studied the kinetic and mechanistic events of HIV-1 protein expression, virion production, and virus transmission and blockade during provirus reactivation. Our results suggest that ART regimens in clinical application of the “shock and kill” approach should contain PIs plus RT inhibitors to simultaneously prevent and inhibit new infection from provirus-activated cells.
SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy
- Journal of Medical Virology
-  5174-5188
-  10.1002/jmv.27965
Intrahost variation and evolutionary dynamics of adenoviruses correlate to neutrophils in infected patients
- Journal of Medical Virology
-  3863-3875
-  10.1002/jmv.27744
Characterization of m6A modifications in the contemporary Zika virus genome and host cellular transcripts
- Journal of Medical Virology
-  4309-4318
-  10.1002/jmv.27869
ORF8 protein of SARS‐CoV‐2 reduces male fertility in mice
- Journal of Medical Virology
-  4193-4205
-  10.1002/jmv.27855
Comparative analyses of small molecule and antibody inhibition on glycoprotein‐mediated entry of Měnglà virus with other filoviruses
- Journal of Medical Virology
-  3263-3269
-  10.1002/jmv.27739
Highlights
- 1.
In our study, we show that previously discovered small-molecule filovirus inhibitors also inhibit Měnglà Virus (MLAV) entry.
- 2.
Using a pseudovirus construct, we found that MLAV requires proteolytic processing for entry but is not dependent on cathepsin B.
- 3.
This is the first study to show MLAV viral entry is biologically distinct but has similarities to Marburg Virus.
SARS‐CoV‐2, SARS‐CoV, and MERS‐CoV encode circular RNAs of spliceosome‐independent origin
- Journal of Medical Virology
-  3203-3222
-  10.1002/jmv.27734
Comparative characterization of SARS‐CoV‐2 variants of concern and mouse‐adapted strains in mice
- Journal of Medical Virology
-  3223-3232
-  10.1002/jmv.27735
Comparison of model‐specific histopathology in mouse models of COVID‐19
- Journal of Medical Virology
-  3605-3612
-  10.1002/jmv.27747
Highlights
We systematically describe and compare the histopathological changes at acute stage of the four types of SARS-CoV-2 infection hACE2 mouse models, which provides a framework that may help in better understanding the pathogenic process of SARS-CoV-2 infection.
Reverse genetics systems for SARS‐CoV‐2
- Journal of Medical Virology
-  3017-3031
-  10.1002/jmv.27738
Evolutionary conservation and positive selection of influenza A nucleoprotein CTL epitopes for universal vaccination
- Journal of Medical Virology
-  2578-2587
-  10.1002/jmv.27662
Highlights
Conserved influenza nucleoprotein fragments across heterosubtypic influenza viruses are identified.
Positively selected influenza nucleoprotein epitopes driven by stable immune selection are identified.
Conserved and positively selected influenza nucleoprotein CTL epitopes can induce potent antigen-specific cellular immunity.
Conserved and positively selected influenza nucleoprotein CTL epitopes can induce cross-protective immunity against heterosubtypic influenza viruses.
Aggregation of high‐frequency RBD mutations of SARS‐CoV‐2 with three VOCs did not cause significant antigenic drift
- Journal of Medical Virology
-  2108-2125
-  10.1002/jmv.27596
Highlights
Infectivity increased by adding three VOCs of V367F, S494P, or A520S.
The infectivity of the three VOCs with multiple high-frequency mutations decreased.
Almost all of the possible variants of the three VOCs did not show severe antigenic drift.
Construction and characterization of two SARS‐CoV‐2 minigenome replicon systems
- Journal of Medical Virology
-  2438-2452
-  10.1002/jmv.27650
Highlights**
We established and characterized two transient, noninfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicon reporter systems, specifically the in vitro transcription-based replicon RNA and the bacterial artificial chromosome-vectored replicon, which will facilitate the COVID-19 basic and antiviral research as well as the development of next-generation SARS-CoV-2 stable replicon systems.
G‐quadruplex ligands inhibit chikungunya virus replication
- Journal of Medical Virology
-  2519-2527
-  10.1002/jmv.27622
Highlights
CHIKV possesses conserved G-quadruplexes
G-quadruplex ligands stabilize CHIKV G-quadruplexes with high affinities
G-quadruplex structures reduce the transcription of the GFP reporter gene containing CHIKV G-quadruplex
G-quadruplex ligands BRACO-19 and TMPyP4 inhibit CHIKV replication
Epidemiological trends and clinical features of the ongoing monkeypox epidemic: A preliminary pooled data analysis and literature review
- Journal of Medical Virology
-  12 June 2022
Genomic annotation and molecular evolution of monkeypox virus outbreak in 2022
- Journal of Medical Virology
-  29 July 2022
Re‐emerging human monkeypox: A major public‐health debacle
- Journal of Medical Virology
-  1 June 2022
Omicron (BA.1) and sub‐variants (BA.1.1, BA.2, and BA.3) of SARS‐CoV‐2 spike infectivity and pathogenicity: A comparative sequence and structural‐based computational assessment
- Journal of Medical Virology
-  4780-4791
-  9 June 2022
The outbreak of SARS‐CoV‐2 Omicron lineages, immune escape, and vaccine effectivity
- Journal of Medical Virology
-  12 September 2022
Differences in incidence and fatality of COVID‐19 by SARS‐CoV‐2 Omicron variant versus Delta variant in relation to vaccine coverage: A world‐wide review
- Journal of Medical Virology
-  2 September 2022
Attaching a stigma to the LGBTQI+ community should be avoided during the monkeypox epidemic
- Journal of Medical Virology
-  2 June 2022
Monkeypox: A potential global threat?
- Journal of Medical Virology
-  4034-4036
-  25 May 2022
The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis
- Journal of Medical Virology
-  5112-5127
-  13 July 2022
Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19
- Journal of Medical Virology
-  9 February 2023
Causal effects of COVID‐19 on cancer risk: A Mendelian randomization study
- Journal of Medical Virology
-  16 April 2023
Association of nirmatrelvir for acute SARS‐CoV‐2 infection with subsequent Long COVID symptoms in an observational cohort study
- Journal of Medical Virology
-  4 January 2024
The association between human papillomavirus and bladder cancer: Evidence from meta‐analysis and two‐sample mendelian randomization
- Journal of Medical Virology
-  12 October 2022
Association between COVID‐19 and telomere length: A bidirectional Mendelian randomization study
- Journal of Medical Virology
-  5345-5353
-  19 July 2022
Stability and transmissibility of SARS‐CoV‐2 in the environment
- Journal of Medical Virology
-  30 August 2022
Presymptomatic viral shedding in high‐risk mpox contacts: A prospective cohort study
- Journal of Medical Virology
-  4 May 2023
Genomic annotation and molecular evolution of monkeypox virus outbreak in 2022
- Journal of Medical Virology
-  29 July 2022
Exploring the dynamics of the 2022 mpox outbreak in Canada
- Journal of Medical Virology
-  6 December 2023
The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection
- Journal of Medical Virology
-  25 April 2023
The signature of SARS‐CoV‐2 evolution reflects selective pressures within human guts
- Journal of Medical Virology
-  29 July 2023
Recent issues
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Volume 96, Issue 4April 2024
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Volume 96, Issue 3March 2024
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Volume 96, Issue 2February 2024
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Volume 96, Issue 1January 2024