- Becker-Hildebrandt House
- Blinn College
- Blue Bell Creameries Complex
- Brenham High School
- Brenham High School Gymnasium
- Brenham School
- Brenham Water Works
- Brockschmidt-Miller House
- East Brenham
- Holle, Edmund, House
- Lenert, Dr. Robert, House
- Matchett, Edgar, House
- Mt. Zion Methodist Church
- Reichardt-Low House
- Santa Fe Railway Company Freight Depot
- Schlenker, Almot, House
- Schlenker-Kolwes House
- Schmidt House
- Schuerenberg, F. W., House
- Schuerenberg, R. A., House
- Seelhorst, W. E., House
- Southern Pacific Railroad Freight Depot
- St. Mary's Catholic Church
- Synagogue B'nai Abraham
- US Post Office-Federal Building-Brenham
- Washington County Courthouse
- Wood-Hughes House
- Brenham Downtown Historic District