The Journal of Pathology

Volume 193, Issue 1 p. 134-140

Original Paper

Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues

Markku H. Vaarala,

Markku H. Vaarala

Biocenter Oulu and World Health Organization Collaborating Centre for Research on Reproductive Health, Oulu, Finland

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Katja S. Porvari,

Katja S. Porvari

Biocenter Oulu and World Health Organization Collaborating Centre for Research on Reproductive Health, Oulu, Finland

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Sakari Kellokumpu,

Sakari Kellokumpu

Department of Anatomy, University of Oulu, Oulu, Finland

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Atte P. Kyllönen,

Atte P. Kyllönen

Department of Pathology, University Hospital of Oulu, Oulu, Finland

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Pirkko T. Vihko,

Corresponding Author

Pirkko T. Vihko

[email protected]

World Health Organization Collaborating Centre for Research on Reproductive Health, Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland

WHO CCR, University of Oulu, P.O. Box 5000, FIN-90014, Finland.Search for more papers by this author

Markku H. Vaarala,

Markku H. Vaarala

Biocenter Oulu and World Health Organization Collaborating Centre for Research on Reproductive Health, Oulu, Finland

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Katja S. Porvari,

Katja S. Porvari

Biocenter Oulu and World Health Organization Collaborating Centre for Research on Reproductive Health, Oulu, Finland

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Sakari Kellokumpu,

Sakari Kellokumpu

Department of Anatomy, University of Oulu, Oulu, Finland

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Atte P. Kyllönen,

Atte P. Kyllönen

Department of Pathology, University Hospital of Oulu, Oulu, Finland

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Pirkko T. Vihko,

Corresponding Author

Pirkko T. Vihko

[email protected]

World Health Organization Collaborating Centre for Research on Reproductive Health, Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland

WHO CCR, University of Oulu, P.O. Box 5000, FIN-90014, Finland.Search for more papers by this author

First published: 06 September 2000

https://doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH743>3.0.CO;2-T

Citations: 124

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Abstract

The purpose of this study was to clarify the expression of TMPRSS2 in mice during development and to compare the tissue distribution of the transcripts in adult mouse and human tissues. Mouse TMPRSS2 cDNA was cloned; the predicted amino acid sequence contains 490 residues sharing 81.4% similarity with human TMPRSS2. According to northern blots, mouse TMPRSS2 is expressed mainly in the prostate and kidney, while human TMPRSS2 is expressed in the prostate, colon, stomach, and salivary gland. In situ hybridization analyses of mouse embryos and adult tissues revealed that TMPRSS2 was expressed in the epithelia of the gastrointestinal, urogenital, and respiratory tracts. Expression was very selective and constant after the gene was turned on during development. Expression of TMPRSS2 was localized in the luminal epithelial cells of the mouse and human prostate. The information presented here will be useful in further studies regarding the function and physiological significance of TMPRSS2. Copyright © 2000 John Wiley & Sons, Ltd.

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Volume193, Issue1

March 2001

Pages 134-140

Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues

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Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues

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