Laboratory Maintenance of Rickettsia rickettsii

This is the seminal article describing the use of a Renografin density gradient for the isolation of pure, viable rickettsiae.

The review article discusses the principles and methods of biosafety regulations as determined by the NIH, the CDC, the WHO and the European Union.

The CDC Rocky Mountain spotted fever Web site. This Web site serves as a good general reference about R. rickettsii natural history, epidemiology, laboratory detection, treatment, prevention, and control.

The CDC Select Agent Program Web site. This Web site lists all select agents and provides information on public laws and regulations regarding research with select agents.

The National Select Agent Registry (NSAR) Web site. This Web site has posted guidelines for compliance with the security requirements of the select agent regulations.

The Belgian Biosafety Server Web site. This Web site has posted guidelines for biosafety in Belgium and the European Union, as well as links to other international biosafety guidelines.

The International Biosafety Working Group Web site. This Web site provides an international forum for the discussion of biosafety issues.

The World Health Organizations Epidemic and Pandemic Alert Response Laboratory Biosafety Manual (third edition) Web site. This Web site provides links for the WHO Laboratory Biosafety manual in English, French, Spanish, Portuguese, Chinese, Russian, Italian, Japanese, Serbian, and Vietnamese.

The CDC Division of Viral and Rickettsial Diseases (DVRD) Web site. This center is one of the WHO Collaborating Reference Centers that work with R. rickettsii. This center is a possible source for obtaining R. rickettsii.

The Unité des Rickettsies at the Faculté de Médecine Web site. This center is also one of the WHO Collaborating Reference Centers that work with R. rickettsii. This center is also a possible source for obtaining R. rickettsii.