Critical Review
Free Access
Clinical impact of blood storage lesions†
Abba C. Zubair,
Corresponding Author
Abba C. Zubair
Transfusion Medicine and Stem Cell therapy, Department of Laboratory Medicine and Pathology, Mayo Clinic, Florida
Transfusion Medicine and Stem Cell therapy, Department of Laboratory Medicine and Pathology, Mayo Clinic, FLSearch for more papers by this author
Abba C. Zubair,
Corresponding Author
Abba C. Zubair
Transfusion Medicine and Stem Cell therapy, Department of Laboratory Medicine and Pathology, Mayo Clinic, Florida
Transfusion Medicine and Stem Cell therapy, Department of Laboratory Medicine and Pathology, Mayo Clinic, FLSearch for more papers by this author
†
Conflict of interest: Nothing to report.
Abstract
Recent reports suggest that transfusion of old red blood cell (RBC) units (>2 weeks) was associated with increased risks of postoperative complications and higher mortality rate caught public attention (Yap et al., Ann Thorac Surg 2008; 86:554–559 and Koch et al., 2008; 358:1229–1239). This rekindled the decades old discussion regarding the impact of RBC aging and storage lesions in patient care. The objectives of this review are to provide readers with an overview of the process of banking RBC that may have an impact on its quality, the reported clinical impact of storage lesions, the consequences of transfusing new RBC units only to the nation's blood supply and potential solutions that may improve the feasibility of blood banks to issue new blood units only. Am. J. Hematol., 2010. © 2009 Wiley-Liss, Inc.
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