Nanocomposite hydrogels for biomedical applications
Akhilesh K. Gaharwar
Department of Biomedical Engineering, Texas A & M University, College Station, Texas, 77843
Search for more papers by this authorCorresponding Author
Nicholas A. Peppas
- [email protected]
- 512-471-6644 | Fax: 512-471-8227
Departments of Chemical Engineering, Biomedical Engineering and Pharmacy, The University of Texas at Austin, Austin, Texas, 78712
Correspondence to: A. Khademhosseini and N.A. PeppasSearch for more papers by this authorCorresponding Author
Ali Khademhosseini
- [email protected]
- 617-388-9271 | Fax: 617-768-8477
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, 02115
Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, 02139
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139
Correspondence to: A. Khademhosseini and N.A. PeppasSearch for more papers by this authorAkhilesh K. Gaharwar
Department of Biomedical Engineering, Texas A & M University, College Station, Texas, 77843
Search for more papers by this authorCorresponding Author
Nicholas A. Peppas
- [email protected]
- 512-471-6644 | Fax: 512-471-8227
Departments of Chemical Engineering, Biomedical Engineering and Pharmacy, The University of Texas at Austin, Austin, Texas, 78712
Correspondence to: A. Khademhosseini and N.A. PeppasSearch for more papers by this authorCorresponding Author
Ali Khademhosseini
- [email protected]
- 617-388-9271 | Fax: 617-768-8477
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, 02115
Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts, 02139
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139
Correspondence to: A. Khademhosseini and N.A. PeppasSearch for more papers by this authorABSTRACT
Hydrogels mimic native tissue microenvironment due to their porous and hydrated molecular structure. An emerging approach to reinforce polymeric hydrogels and to include multiple functionalities focuses on incorporating nanoparticles within the hydrogel network. A wide range of nanoparticles, such as carbon-based, polymeric, ceramic, and metallic nanomaterials can be integrated within the hydrogel networks to obtain nanocomposites with superior properties and tailored functionality. Nanocomposite hydrogels can be engineered to possess superior physical, chemical, electrical, and biological properties. This review focuses on the most recent developments in the field of nanocomposite hydrogels with emphasis on biomedical and pharmaceutical applications. In particular, we discuss synthesis and fabrication of nanocomposite hydrogels, examine their current limitations and conclude with future directions in designing more advanced nanocomposite hydrogels for biomedical and biotechnological applications. Biotechnol. Bioeng. 2014;111: 441–453. © 2013 Wiley Periodicals, Inc.
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