Volume 30, Issue 2 p. E386-E394
Mutation in Brief
Free Access

Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation

Mannis van Oven

Corresponding Author

Mannis van Oven

Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands

Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The NetherlandsSearch for more papers by this author
Manfred Kayser

Manfred Kayser

Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands

Search for more papers by this author
First published: 13 October 2008
Citations: 1,320

Communicated by Peter J. Oefner

Abstract

Human mitochondrial DNA is widely used as tool in many fields including evolutionary anthropology and population history, medical genetics, genetic genealogy, and forensic science. Many applications require detailed knowledge about the phylogenetic relationship of mtDNA variants. Although the phylogenetic resolution of global human mtDNA diversity has greatly improved as a result of increasing sequencing efforts of complete mtDNA genomes, an updated overall mtDNA tree is currently not available. In order to facilitate a better use of known mtDNA variation, we have constructed an updated comprehensive phylogeny of global human mtDNA variation, based on both coding- and control region mutations. This complete mtDNA tree includes previously published as well as newly identified haplogroups, is easily navigable, will be continuously and regularly updated in the future, and is online available at http://www.phylotree.org. © 2008 Wiley-Liss, Inc.

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