Brief Mapping Report
Human Neuropilin-1 and Neuropilin-2 Map to 10p12 and 2q34, Respectively☆
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Neuropilin is a receptor for the axonal chemorepellent semaphorin III
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Cited by (22)
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Lymphangiogenesis and metastasis-A closer look at the neuropilin/semaphorin3 axis
2014, Microvascular ResearchCitation Excerpt :The NRP family consists of two distinct 130 kDa transmembrane glycoproteins—NRP1 and NRP2. The two proteins are structurally similar, sharing 44% amino acid homology, yet map to separate chromosomes (NRP1:10p12; NRP2:2q34) (Giger et al., 1998; Rossignol et al., 1999). The structure of both NRP receptors consists of five extracellular domains (a1, a2, b1, b2, and c), a transmembrane domain, and a short intracellular domain with a PDZ binding motif (Klagsbrun and Eichmann, 2005; Bielenberg et al., 2006).
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Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas
2014, Laboratory Investigation -
17 Immunohistochemical localization of neuropilin-1 in human. A possible molecular marker for diagnosis
2002, Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas -
Neuropilins as Cancer Biomarkers: A Focus on Neuronal Origin and Specific Cell Functions
2022, Biomarkers of the Tumor Microenvironment, Second Edition
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This work was supported by NIH Grants CA37392 (M.K.) and CA45548. M.R. was sponsored by an EMBO long-term fellowship. A.H.B. is supported by NIH AR44345 and AR02026.
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