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N-Acetylaspartate pp 77–93Cite as

Canavan Disease: Studies on the Knockout Mouse

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 576))

1. Abstract

Canavan disease (CD) is an autosomal recessive disorder, characterized by spongy degeneration of the brain. Patients with CD have aspartoacylase (ASPA) deficiency, which results accumulation of N-acetylaspartic acid (NAA) in the brain and elevated excretion of urinary NAA. Clinically, patients with CD have macrocephaly, mental retardation and hypotonia. A knockout mouse for CD which was engineered, also has ASPA deficiency and elevated NAA. Molecular studies of the mouse brain showed abnormal expression of multiple genes in addition to ASPA deficiency. Adenoassociated virus mediated gene transfer and stem cell therapy in the knockout mouse are the latest attempts to alter pathophysiology in the CD mouse.

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Authors and Affiliations

  1. Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, 77555

    Dr. Reuben Matalon, Kimberlee Michals-Matalon, Sankar Surendran & Stephen K. Tyring

  2. Department of Dermatology, University of Texas Health Science Center, Houston, TX, 77030

    Stephen K. Tyring

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  1. Dr. Reuben Matalon
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  2. Kimberlee Michals-Matalon
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  3. Sankar Surendran
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  4. Stephen K. Tyring
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Correspondence to Reuben Matalon .

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Editors and Affiliations

  1. Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA

    John R. Moffett  & Aryan M. A. Namboodiri  & 

  2. University of Albany, Albany, NY, 12222, USA

    Suzannah B. Tieman

  3. National Institute of Mental Health, Bethesda, MD, 20814, USA

    Daniel R. Weinberger

  4. McLean Hospital, Belmont, MA, 02178, USA

    Joseph T. Coyle

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Matalon, R., Michals-Matalon, K., Surendran, S., Tyring, S.K. (2006). Canavan Disease: Studies on the Knockout Mouse. In: Moffett, J.R., Tieman, S.B., Weinberger, D.R., Coyle, J.T., Namboodiri, A.M.A. (eds) N-Acetylaspartate. Advances in Experimental Medicine and Biology, vol 576. Springer, Boston, MA . https://doi.org/10.1007/0-387-30172-0_6

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