Abstract
The coronaviruses are a group of RNA-containing agents that have been associated with respiratory illnesses in man and with a number of other diseases in laboratory and domestic animals. The name for the group was adopted to describe the characteristic fringe of crownlike projections seen around the viruses by electron microscopy; these projections are rounded, rather than sharp or pointed as is the case with the myxoviruses. Like the myxoviruses, the coronaviruses contain essential lipid and are 80–160 nm in diameter.(18) While the animal strains are readily isolated in several different systems, recovery of the human strains has posed major problems. A number of these strains have been isolated only in organ culture of the human respiratory tract. This factor has made it difficult to determine the relationship among isolates and has complicated efforts to understand the role of these viruses in human respiratory illness. Therefore, much of the information on the epidemiology of the agents has come from serological studies.
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Keywords
- Infectious Bronchitis Virus
- Strain 229E
- Coronavirus Infection
- Human Coronaviruses
- Avian Infectious Bronchitis Virus
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Suggested Reading
Bradburne, A. F., and Tyrrell, D. A. J., Coronaviruses of man, Prog. Med. Virol. 13: 373–403 (1971).
Hamre, D., and Berm, M., Virologic studies of acute respiratory disease in young adults. V. Coronavirus 229E infections during six years of surveillance, Am. J. Epidemiol. 96: 94–106 (1972).
Kaye, H. S., Marsh, H. B., and Dowdle, W. R., Seroepidemiologic survey of coronavirus (strain 0C43) related infections in a children’s population, Am. J. Epidemiol. 94: 43–49 (1971).
Mcintosh, K., Kapikian, A. Z., Turner, H. C., Hartley, J. W., Parrott, R. H., and Chanock, R. M., Seroepidemiologic studies of coronavirus infection in adults and children, Am. J. Epidemiol. 91: 585–592 (1970).
Monto, A. S., and Lim, S. K., The Tecumseh study of respiratory illness. VI. Frequency of and relationship between outbreaks of coronavirus infection, J. Infect. Dis. 129: 271–276 (1974).
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Monto, A.S. (1984). Coronaviruses. In: Evans, A.S. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4727-9_7
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