Abstract
In prolonged exercise the plasma level of branched-chain amino acids (BCAA) may fall and that of fatty acid increases: the latter increases the free tryptophan level, so that the plasma concentration ratio, free tryptophan/BCAA may increase leading to higher levels of tryptophan and therefore of 5-hydroxytryptamine (5-HT) in brain. The latter increases the activity of some 5-HT neurons in the brain which can cause sleep and which could, therefore, increase the mental effort necessary to maintain athletic activity. Drinks containing branched-chain amino acids should restore vigor to athletes whose performance is depressed by an excess of cerebral 5-HT. Recent work suggests that intake of branched-chain amino acids may improve performance in slower runners in the marathon and decrease perceived physical and mental exertion in laboratory experiments. This suggestion is supported by pharmacological manipulations that result in either increased or decreased physical performance.
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References
Bailey SP, Davis JM & Ahlborn EA (1992). Effect of increased brain serotonergic activity on endurance performance in the rat. Acta Physiologica Scandinavica 145, 75–76.
Bailey SP, Davis JM & Ahlborn EA (1993). Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue. Journal of Applied Physiology 74, 3006–3012.
Blomstrand E, Celsing F & Newsholme EA (1988). Changes in plasma concentrations of aromatic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue. Acta Physiologica Scandinavica 133, 115–121.
Blomstrand E, Hassmén P, Ekblom B & Newsholme EA (1991a). Administration of branched-chain amino acids during sustained exercise—effects on performance and on plasma concentration of some amino acids. European Journal of Applied Physiology 63, 83–88.
Blomstrand E, Hassmén P & Newsholme EA (1991b). Effect of branched-chain amino acid supplementation on mental performance. Acta Physiologica Scandinavica 143, 225–226.
Blomstrand E, Perrett D, Parry-Billings M & Newsholme EA (1989). Effect of sustained exercise on plasma amino acid concentrations and on 5-hydroxytryptamine metabolism in six different brain regions of the rat. Acta Physiologica Scandinavica 136, 473–481.
Cowen PJ, Anderson IM & Grahame-Smith DG (1990). Neuroendocrine effects of azapirones. Journal of Clinical Psychopharmacology 10, 215–255.
Davis JM, Bailey SP, Woods JA, Galiano FJ, Hamilton MT & Bartoli WP (1992). Effects of carbohydrate feedings on plasma free tryptophan and branched-chain amino acids during prolonged cycling. European Journal of Applied Physiology 65, 513–519
Fernstrom JD (1990). Aromatic amino acids and monamine synthesis in the CNS: influence of diet. Journal of Nutritional Biochemistry 10, 508–517.
Jakeman PM, Hawthorne JE, Maxwell SRJ, Kendall MJ & Holder G (1994). Evidence for down regulation of hypothalamic 5-hydroxytryptamine receptor function in endurance-trained athletes. Experimental Physiology 79, 461–464.
Newsholme EA (1986). Application of knowledge of metabolic integration to the problem of metabolic limitations in middle distance and marathon running. Acta Physiologica Scandinavica 128 (suppl. 556), 93–97.
Newsholme EA, Blomstrand E, Hassmén P & Ekblom B (1991). Physical and mental fatigue: do changes in plasma amino acids play a role? Biochemical Society Transactions 19, 358–362
Newsholme EA, & Leech AR (1983). Biochemistry for the Medical Sciences. Chichester, England: John Wiley & Sons.
Okamura K, Matsubara F, Yoshioka Y, Kikuchi N, Kikuchi Y & Kohri H (1987). Exercise-induced changes in branched chain amino acid/aromatic amino acid ratio in the rat brain and plasma. Japanese Journal of Pharmacology 45, 243–248.
Wilson WM & Maughan RJ (1992). Evidence for a possible role of 5-hydroxytryptamine in the genesis of fatigue in man: administration of paroxetine, a 5-HT re-uptake inhibitor, reduces the capacity to perform prolonged exercise. Experimental Physiology 77, 921–924.
Wright DA, Sherman WM & Dernbach AR (1991). Carbohydrate feedings before, during or in combination improve cycling endurance performance. Journal of Applied Physiology 71, 1082–1088.
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Newsholme, E.A., Blomstrand, E. (1995). Tryptophan, 5-Hydroxytryptamine and a Possible Explanation for Central Fatigue. In: Gandevia, S.C., Enoka, R.M., McComas, A.J., Stuart, D.G., Thomas, C.K., Pierce, P.A. (eds) Fatigue. Advances in Experimental Medicine and Biology, vol 384. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1016-5_25
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DOI: https://doi.org/10.1007/978-1-4899-1016-5_25
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