Summary
It is proposed that the first entity capable of adaptive Darwinian evolution consisted of a liposome vesicle formed of (1) abiotically produced phospholipidlike molecules; (2) a very few informational macromolecules; and (3) some abiogenic, lipid-soluble, organic molecule serving as a symporter for phosphate and protons and as a means of high-energy-bond generation. The genetic material had functions that led to the production of phospholipidlike materials (leading to growth and division of the primitive cells) and of the carrier needed for energy transduction. It is suggested that the most primitive exploitable energy source was the donation of 2H++2e− at the external face of the primitive cell. The electrons were transferred (by metal impurities) to internal sinks of organic material, thus creating, via a deficit, a protonmotive force that could drive both the active transport of phosphate and high-energy-bond formation.
This model implies that proton translocation in a closed-membrane system preceded photochemical or electron transport mechanisms and that chemically transferable metabolic energy was needed at a much earlier stage in the development of life than has usually been assumed. It provides a plausible mechanism whereby cell division of the earliest protocells could have been a spontaneous process powered by the internal development of phospholipids. The stimulus for developing this evolutionary sequence was the realization that cellular life was essential if Darwinian “survival of the fittest” was to direct evolution toward adaptation to the external environment.
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References
Deamer DW, Barchfeld GL (1982) Encapsulation of macromolecules by lipid vesicles under simulated prebiotic conditions. J Mol Evol 18:203–206
Deamer DW, Nichols JW (1983) Proton-hydroxide permeability of lyposomes. Proc Natl Acad Sci USA 80:165–168
Deamer DW, Oro J (1980) Role of lipids in prebiotic structures. Biosystems 12:167–175
Eigen M, Schuster P (1979) The hypercycle, a principle of natural self-organization. Springer-Verlag, Berlin
Ferguson SJ, Sorgato MC (1982) Proton electrochemical gradients and energy-transduction processes. Annu Rev Biochem 51:185–217
Fillingame RH (1980) The proton-translocating pumps of oxidative phosphorylation. Annu Rev Biochem 49:1079–1113
Folsome CE, Morowitz H (1969) Prebiological membranes: synthesis and properties. Space Life Sci 1:538–544
Gest H (1980) The evolution of biological energy-transducing systems. FEMS Micro Lett 7:73–77
Goldacre RJ (1958) Surface films: their collapse on compression, the shapes and sizes of cells, and the origin of life. In: Danielli JF, Pankhurst KGA, Riddiford AC (eds) Surface phenomena in biology and chemistry. Pergamon, New York, pp 278–298
Haldane JBS (1954) The origins of life. In: Johnson ML, Abercromble M (eds) New biology, vol. 16. Penguin, London, pp 12–27
Hargreaves WR, Deamer DW (1978a) Origin and early evolution of bilayer membranes. In: Deamer DW (ed) Light transducing membranes. Academic Press, New York, pp 23–60
Hargreaves WR, Deamer DW (1978b) Lysosomes from ionic, single chain amphiphiles. Biochemistry 17:3759–3768
Jain MK, Wagner RS (1980) Introduction to biological membranes. John Wiley & Sons, New York
Koch AL (1983) The surface stress theory of microbial morphogenesis. Adv Microb Physiol 24:301–366
Koch AL (1984) Evolution vs. the number of gene copies per primitive cell. J Mol Evol 20:71–76
Koch AL, Mobley HLT, Doyle RJ, Streips UN (1981) The coupling of wall growth and chromosome replication in gram positive rods. FEMS Micro Lett 12:201–208
Lugtenberg B, van Alphen L (1983) Molecular architecture and functioning of the outer membrane ofEscherichia coli and other Gram-negative bacteria. Biochim Biophys Acta 737:51–115
Matsuno K (1980) Compartmentalization of self-reproducing machineries: multiplication of microsystems with self-instructing polymerization of amino acids. Orig Life 10:361–370
Miller SL (1953) A production of amino acids under possible primitive Earth conditions. Science 117:528–529
Mitchell P (1968) Chemiosmotic coupling and energy transduction. Glynn Research Ltd., Bodmin, Cornwall, England
Morowitz H (1968) Energy flow in biology. Ox Bow Press, Woodbridge, Connecticut
Niesert U, Harnasch D, Bresch C (1981) Origin of life between Scylla and Charybdis. J Mol Evol 17:348–353
Odum JM, Peck HD (1981) Hydrogen cycling as a general mechanism for energy coupling in sulfate reducing bacteria,Desulfovibrio sp. FEMS Micro Lett 12:47–50
Oparin AI (1953) The origin of life, 3rd ed (translated by S Morgulis). MacMillan, New York
Oro J, Sherwood E, Eichberg J, Eppo DE (1978) Formation of phospholipids under primitive Earth conditions and the role of membranes in prebiological evolution. In: Deamer DW (ed) Light transducing membranes. Academic Press, New York, pp 1–19
Oro J, Holzer G, Rao M, Tornabene T (1980) Membrane lipids and the origin of life. In: Wolman Y (ed) Origin of life. D Reidel, Dordrecht, The Netherlands, pp 313–322
Papahadjopoulos D (1978) Calcium-induced phase changes and fusion in model membranes. In: Poste G, Nicholson GL (eds) Membrane fusion. North-Holland, Amsterdam, pp 766–790
Papahadjopoulos D, Poste G, Schaeffer BE, Vail WJ (1974) Membrane fusion and molecular segregation in phospholipid vesicles. Biochim Biophys Acta 352:10–28
Rao M, Eichberg J, Oro J (1982) Synthesis of phosphatidylcholine under possible primitive Earth conditions. J Mol Evol 18:196–202
Raven JA, Smith FA (1982) Solute transport at the plasmalemma and early evolution of cells. Biosystems 15:13–26
Shah DO (1972) The origin of membranes and related surface phenomena. In: Ponnamperuma C (ed) Exobiology. North Holland, Amsterdam, pp 235–265
Smith TF, Morowitz HJ (1982) Between history and physics. J Mol Evol 18:265–282
Stillwell W (1980) Facilitated diffusion as a method for selective accumulation of materials from the primordial oceans by a lipid-vesicle protocell. Orig Life 10:277–292
Tanford C (1980) The hydrophobic effect: formation of micelles and biological membranes, 2nd ed. Wiley-Interscience, New York
Tien HT (1974) Bilayer lipid membranes: theory and practice. Marcel Dekker, New York
Wilson TH, Lin ECC (1980) Evolution of membrane bioenergetics. J Supra Struct 13:421–446
Wood PM (1978) A chemiosmotic model for sulfate respiration. FEBS Lett 95:12–18
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Koch, A.L. Primeval cells: Possible energy-generating and cell-division mechanisms. J Mol Evol 21, 270–277 (1985). https://doi.org/10.1007/BF02102359
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DOI: https://doi.org/10.1007/BF02102359