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Primeval cells: Possible energy-generating and cell-division mechanisms

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Summary

It is proposed that the first entity capable of adaptive Darwinian evolution consisted of a liposome vesicle formed of (1) abiotically produced phospholipidlike molecules; (2) a very few informational macromolecules; and (3) some abiogenic, lipid-soluble, organic molecule serving as a symporter for phosphate and protons and as a means of high-energy-bond generation. The genetic material had functions that led to the production of phospholipidlike materials (leading to growth and division of the primitive cells) and of the carrier needed for energy transduction. It is suggested that the most primitive exploitable energy source was the donation of 2H++2e at the external face of the primitive cell. The electrons were transferred (by metal impurities) to internal sinks of organic material, thus creating, via a deficit, a protonmotive force that could drive both the active transport of phosphate and high-energy-bond formation.

This model implies that proton translocation in a closed-membrane system preceded photochemical or electron transport mechanisms and that chemically transferable metabolic energy was needed at a much earlier stage in the development of life than has usually been assumed. It provides a plausible mechanism whereby cell division of the earliest protocells could have been a spontaneous process powered by the internal development of phospholipids. The stimulus for developing this evolutionary sequence was the realization that cellular life was essential if Darwinian “survival of the fittest” was to direct evolution toward adaptation to the external environment.

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References

  • Deamer DW, Barchfeld GL (1982) Encapsulation of macromolecules by lipid vesicles under simulated prebiotic conditions. J Mol Evol 18:203–206

    PubMed  Google Scholar 

  • Deamer DW, Nichols JW (1983) Proton-hydroxide permeability of lyposomes. Proc Natl Acad Sci USA 80:165–168

    PubMed  Google Scholar 

  • Deamer DW, Oro J (1980) Role of lipids in prebiotic structures. Biosystems 12:167–175

    PubMed  Google Scholar 

  • Eigen M, Schuster P (1979) The hypercycle, a principle of natural self-organization. Springer-Verlag, Berlin

    Google Scholar 

  • Ferguson SJ, Sorgato MC (1982) Proton electrochemical gradients and energy-transduction processes. Annu Rev Biochem 51:185–217

    PubMed  Google Scholar 

  • Fillingame RH (1980) The proton-translocating pumps of oxidative phosphorylation. Annu Rev Biochem 49:1079–1113

    PubMed  Google Scholar 

  • Folsome CE, Morowitz H (1969) Prebiological membranes: synthesis and properties. Space Life Sci 1:538–544

    PubMed  Google Scholar 

  • Gest H (1980) The evolution of biological energy-transducing systems. FEMS Micro Lett 7:73–77

    Google Scholar 

  • Goldacre RJ (1958) Surface films: their collapse on compression, the shapes and sizes of cells, and the origin of life. In: Danielli JF, Pankhurst KGA, Riddiford AC (eds) Surface phenomena in biology and chemistry. Pergamon, New York, pp 278–298

    Google Scholar 

  • Haldane JBS (1954) The origins of life. In: Johnson ML, Abercromble M (eds) New biology, vol. 16. Penguin, London, pp 12–27

    Google Scholar 

  • Hargreaves WR, Deamer DW (1978a) Origin and early evolution of bilayer membranes. In: Deamer DW (ed) Light transducing membranes. Academic Press, New York, pp 23–60

    Google Scholar 

  • Hargreaves WR, Deamer DW (1978b) Lysosomes from ionic, single chain amphiphiles. Biochemistry 17:3759–3768

    PubMed  Google Scholar 

  • Jain MK, Wagner RS (1980) Introduction to biological membranes. John Wiley & Sons, New York

    Google Scholar 

  • Koch AL (1983) The surface stress theory of microbial morphogenesis. Adv Microb Physiol 24:301–366

    PubMed  Google Scholar 

  • Koch AL (1984) Evolution vs. the number of gene copies per primitive cell. J Mol Evol 20:71–76

    PubMed  Google Scholar 

  • Koch AL, Mobley HLT, Doyle RJ, Streips UN (1981) The coupling of wall growth and chromosome replication in gram positive rods. FEMS Micro Lett 12:201–208

    Google Scholar 

  • Lugtenberg B, van Alphen L (1983) Molecular architecture and functioning of the outer membrane ofEscherichia coli and other Gram-negative bacteria. Biochim Biophys Acta 737:51–115

    PubMed  Google Scholar 

  • Matsuno K (1980) Compartmentalization of self-reproducing machineries: multiplication of microsystems with self-instructing polymerization of amino acids. Orig Life 10:361–370

    PubMed  Google Scholar 

  • Miller SL (1953) A production of amino acids under possible primitive Earth conditions. Science 117:528–529

    PubMed  Google Scholar 

  • Mitchell P (1968) Chemiosmotic coupling and energy transduction. Glynn Research Ltd., Bodmin, Cornwall, England

    Google Scholar 

  • Morowitz H (1968) Energy flow in biology. Ox Bow Press, Woodbridge, Connecticut

    Google Scholar 

  • Niesert U, Harnasch D, Bresch C (1981) Origin of life between Scylla and Charybdis. J Mol Evol 17:348–353

    PubMed  Google Scholar 

  • Odum JM, Peck HD (1981) Hydrogen cycling as a general mechanism for energy coupling in sulfate reducing bacteria,Desulfovibrio sp. FEMS Micro Lett 12:47–50

    Google Scholar 

  • Oparin AI (1953) The origin of life, 3rd ed (translated by S Morgulis). MacMillan, New York

    Google Scholar 

  • Oro J, Sherwood E, Eichberg J, Eppo DE (1978) Formation of phospholipids under primitive Earth conditions and the role of membranes in prebiological evolution. In: Deamer DW (ed) Light transducing membranes. Academic Press, New York, pp 1–19

    Google Scholar 

  • Oro J, Holzer G, Rao M, Tornabene T (1980) Membrane lipids and the origin of life. In: Wolman Y (ed) Origin of life. D Reidel, Dordrecht, The Netherlands, pp 313–322

    Google Scholar 

  • Papahadjopoulos D (1978) Calcium-induced phase changes and fusion in model membranes. In: Poste G, Nicholson GL (eds) Membrane fusion. North-Holland, Amsterdam, pp 766–790

    Google Scholar 

  • Papahadjopoulos D, Poste G, Schaeffer BE, Vail WJ (1974) Membrane fusion and molecular segregation in phospholipid vesicles. Biochim Biophys Acta 352:10–28

    PubMed  Google Scholar 

  • Rao M, Eichberg J, Oro J (1982) Synthesis of phosphatidylcholine under possible primitive Earth conditions. J Mol Evol 18:196–202

    PubMed  Google Scholar 

  • Raven JA, Smith FA (1982) Solute transport at the plasmalemma and early evolution of cells. Biosystems 15:13–26

    PubMed  Google Scholar 

  • Shah DO (1972) The origin of membranes and related surface phenomena. In: Ponnamperuma C (ed) Exobiology. North Holland, Amsterdam, pp 235–265

    Google Scholar 

  • Smith TF, Morowitz HJ (1982) Between history and physics. J Mol Evol 18:265–282

    PubMed  Google Scholar 

  • Stillwell W (1980) Facilitated diffusion as a method for selective accumulation of materials from the primordial oceans by a lipid-vesicle protocell. Orig Life 10:277–292

    PubMed  Google Scholar 

  • Tanford C (1980) The hydrophobic effect: formation of micelles and biological membranes, 2nd ed. Wiley-Interscience, New York

    Google Scholar 

  • Tien HT (1974) Bilayer lipid membranes: theory and practice. Marcel Dekker, New York

    Google Scholar 

  • Wilson TH, Lin ECC (1980) Evolution of membrane bioenergetics. J Supra Struct 13:421–446

    Google Scholar 

  • Wood PM (1978) A chemiosmotic model for sulfate respiration. FEBS Lett 95:12–18

    PubMed  Google Scholar 

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Koch, A.L. Primeval cells: Possible energy-generating and cell-division mechanisms. J Mol Evol 21, 270–277 (1985). https://doi.org/10.1007/BF02102359

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  • DOI: https://doi.org/10.1007/BF02102359

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