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Collagen scaffolds for orthopedic regenerative medicine

  • Biomaterials for Regenerative Medicine
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Abstract

Collagen and collagen-based scaffolds offer distinct advantages when selected as biomaterials for use across a broad spectrum of regenerative medicine applications. However, relatively poor mechanical properties are often perceived to limit their usefulness for orthopedic applications. These problems can be overcome through enhanced crosslinking mechanisms or through the addition of a second, stiffer phase such as hydroxyapatite, thus allowing tailored composite scaffolds to meet specific tissue requirements. This overview will highlight the current state of the art of these scaffolds, and consider the exciting prospects and future directions of collagen-based technologies for orthopedic regenerative medicine.

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References

  1. R. Langer and J.P. Vacanti, Science, 260(5110) (1993), pp. 920–926.

    CAS  Google Scholar 

  2. A. Atala et al., Lancet, 367(9518) (2006), pp. 1241–1246.

    Google Scholar 

  3. T. Dvir et al., Nat. Nano., 6(1) (2011), pp. 13–22.

    CAS  Google Scholar 

  4. F.J. O’Brien et al., Technol. Health Care, 15(1) (2007), pp. 3–17.

    Google Scholar 

  5. F.J. O’Brien et al., Biomaterials, 26(4) (2005), pp. 433–441.

    Google Scholar 

  6. D.W. Hutmacher, Biomaterials, 21(24) (2000), pp. 2529–2543.

    CAS  Google Scholar 

  7. B.A. Harley et al., Acta Biomater., 3(4) (2007), pp. 463–474.

    CAS  Google Scholar 

  8. C.M. Murphy et al., Biomaterials, 31(3) (2010), pp. 461–466.

    CAS  Google Scholar 

  9. K. Gelse et al., Adv. Drug Deliv. Rev., 55(12) (2003), pp. 1531–1546.

    CAS  Google Scholar 

  10. J.L. Chen et al., Biomaterials, 31(36) (2010), pp. 9438–9451.

    CAS  Google Scholar 

  11. Z. Ruszczak, Adv. Drug Deliv. Rev., 55(12) (2003), pp. 1595–1611.

    CAS  Google Scholar 

  12. Y.-B. Lee et al., Experimental Neurology, 223(2) (2010), pp. 645–652.

    CAS  Google Scholar 

  13. Z. Chen et al., Brain Research, 1368 (January 2011), pp. 71–81.

    CAS  Google Scholar 

  14. N. Davidenko et al., Acta Biomater., 6(10) (2010), pp. 3957–3968.

    CAS  Google Scholar 

  15. Y. Sumita et al., Biomaterials, 27(17) (2006), pp. 3238–3248.

    CAS  Google Scholar 

  16. Y. Zhang et al., Biochem. Biophys. Res. Comm., 344(1) (2006), pp. 362–369.

    CAS  Google Scholar 

  17. J. Riesle et al., J. Cell Biochem., 71(3) (1998), pp. 313–327.

    CAS  Google Scholar 

  18. T. Aigner and J. Stöve, Adv. Drug Deliv. Rev., 55(12) (2003), pp. 1569–1593.

    CAS  Google Scholar 

  19. I.V. Yannas and J.F. Burke, J. Biomed. Mater. Res., 14(1) (1980), pp. 65–81.

    CAS  Google Scholar 

  20. C.H. Lee et al., Int. J. Pharm., 221(1–2) (2001), pp. 1–22.

    CAS  Google Scholar 

  21. M. Geiger et al., Adv. Drug Deliv. Rev., 55(12) (2003), pp. 1613–1629.

    CAS  Google Scholar 

  22. W. Friess, Eur. J. Pharm. Biopharm., 45(2) (1998), pp. 113–136.

    CAS  Google Scholar 

  23. J.S. Pieper et al., Biomaterials, 20(9) (1999), pp. 847–858.

    CAS  Google Scholar 

  24. F.J. O’Brien et al., Biomaterials, 25(6) (2004), pp. 1077–1086.

    Google Scholar 

  25. S.P. Zhong et al., Mater. Sci. Eng. C, 27(2) (2007), pp. 262–266.

    CAS  Google Scholar 

  26. E. Sachlos et al., Biomaterials, 24(8) (2003), pp. 1487–1497.

    CAS  Google Scholar 

  27. E. Sachlos et al., Acta Biomater., 4(5) (2008), pp. 1322–1331.

    CAS  Google Scholar 

  28. S. Nade et al., Clin. Orthop. Relat. Res. (181) (1983), pp. 255–263.

  29. H.W. Denissen et al., J. Biomed. Mater. Res., 14(6) (1980), pp. 713–721.

    CAS  Google Scholar 

  30. M.G. Haugh et al., J. Biomed. Mater. Res. A, 89A(2) (2009), pp. 363–369.

    CAS  Google Scholar 

  31. M.G. Haugh et al., Tissue Eng. Part A (17 January 2011), doi:10.1089/ten.tea.2010.0590.

  32. K. Weadock et al., Biomater. Med. Devices Artif. Organs, 11(4) (1983), pp. 293–318.

    Google Scholar 

  33. M. Kikuchi et al., Biomaterials, 25(1) (2004), pp. 63–69.

    CAS  Google Scholar 

  34. E. Jorge-Herrero et al., Biomaterials, 20(6) (1999), pp. 539–545.

    CAS  Google Scholar 

  35. CR Lee et al., Biomaterials, 22(23) (2001), pp. 3145–3154.

    CAS  Google Scholar 

  36. R.-N. Chen et al., Biomaterials, 26(20) (2005), pp. 4229–4235.

    CAS  Google Scholar 

  37. D.Y.S. Chau et al., Biomaterials, 26(33) (2005), pp. 6518–6529.

    CAS  Google Scholar 

  38. G. Wollensak et al., Am. J. Ophthalmol., 135(5) (2003), pp. 620–627.

    CAS  Google Scholar 

  39. G. Wollensak and E. Spoerl, J. Cataract Refract. Surg., 30(3) (2004), pp. 689–695.

    Google Scholar 

  40. C.M. Dong et al., Biomaterials, 26(18) (2005), pp. 4041–4049.

    CAS  Google Scholar 

  41. S.D. Gorham et al., Int. J. Biol. Macromol., 14(3) (1992), pp. 129–138.

    CAS  Google Scholar 

  42. C.M. Tierney et al., J. Mech. Behav. Biomed. Mater., 2(2) (2009), pp. 202–209.

    Google Scholar 

  43. K.S. Weadock et al., J. Biomed. Mater. Res., 29(11) (1995), pp. 1373–1379.

    CAS  Google Scholar 

  44. L.H.H. Olde Damink et al., Biomaterials, 17(7) (1996), pp. 679–684.

    CAS  Google Scholar 

  45. J.S. Pieper et al., Biomaterials, 21(6) (2000), pp. 581–593.

    CAS  Google Scholar 

  46. H.M. Powell and S.T. Boyce, Biomaterials, 27(34) (2006), pp. 5821–5827.

    CAS  Google Scholar 

  47. G.C. Steffens et al., Tissue Eng., 10(9–10) (2004), pp. 1502–1509.

    CAS  Google Scholar 

  48. E. Marzec and K. Pietrucha, Biophys. Chem., 132(2–3) (2008), pp. 89–96.

    CAS  Google Scholar 

  49. D.M. Veríssimo et al., Acta Biomater., 6(10) (2010), pp. 4011–4018.

    Google Scholar 

  50. L. Ma et al., Biomaterials, 25(15) (2004), pp. 2997–3004.

    CAS  Google Scholar 

  51. B.A.C. Harley and L.J. Gibson, Chem. Eng. J., 137(1) (2008), pp. 102–121.

    CAS  Google Scholar 

  52. J.L.C. van Susante et al., Biomaterials, 22(17) (2001), pp. 2359–2369.

    Google Scholar 

  53. N.T. Dai et al., Biomaterials, 25(18) (2004), pp. 4263–4271.

    CAS  Google Scholar 

  54. A.G.A. Coombes et al., Biomaterials, 23(10) (2002), pp. 2113–2118.

    CAS  Google Scholar 

  55. W. He et al., Tissue Eng., 11(9–10) (2005), pp. 1574–1588.

    CAS  Google Scholar 

  56. A. Sosnik and M.V. Sefton, Biomaterials, 26(35) (2005), pp. 7425–7435.

    CAS  Google Scholar 

  57. T. Sato et al., Mater. Sci. Eng. C, 17(1–2) (2001), pp. 83–89.

    CAS  Google Scholar 

  58. J. Li et al., Acta Biomater., 6(6) (2010), pp. 2013–2019.

    CAS  Google Scholar 

  59. T. Sato et al., Mater. Sci. Eng. C, 24(3) (2004), pp. 365–372.

    Google Scholar 

  60. X. Li et al., Mater. Sci. Eng. C, 26(4) (2006), pp. 716–720.

    CAS  Google Scholar 

  61. W. Dai et al., Biomaterials, 31(8) (2010), pp. 2141–2152.

    CAS  Google Scholar 

  62. S. Liao et al., Biomaterials, 26(36) (2005), pp. 7564–7571.

    CAS  Google Scholar 

  63. J.F. Burke et al., Ann. Surg., 194(4) (1981), pp. 413–428.

    CAS  Google Scholar 

  64. E. Farrell et al., Tissue Eng., 12(3) (2006), pp. 459–468.

    CAS  Google Scholar 

  65. C. Tierney, M et al., J. Biomed. Mater. Res. A, 91A(1) (2009), pp. 92–101.

    CAS  Google Scholar 

  66. M.B. Keogh et al., Acta Biomater., 6(11) (2010), pp. 4305–4313.

    CAS  Google Scholar 

  67. J.S. Pieper et al., Biomaterials, 21(16) (2000), pp. 1689–1699.

    CAS  Google Scholar 

  68. C.M. Murphy and F.J. O’Brien, Cell Adh. Migr., 4(3) (2010), pp. 377–381.

    Google Scholar 

  69. R. Docherty et al., J. Cell Sci., 92(Pt 2) (1989), pp. 263–270.

    CAS  Google Scholar 

  70. D. Schulz Torres et al., Biomaterials, 21(15) (2000), pp. 1607–1619.

    Google Scholar 

  71. J.E. Lee et al., Biomaterials, 25(18) (2004), pp. 4163–4173.

    CAS  Google Scholar 

  72. J.K. Francis Suh, Biomaterials, 21(24) (2000), pp. 2589–2598.

    CAS  Google Scholar 

  73. M.N. Taravel and A Domard, Biomaterials, 17(4) (1996), pp. 451–455.

    CAS  Google Scholar 

  74. A.A. Al-Munajjed and F.J. O’Brien, J. Mech. Behav. Biomed. Mater., 2(2) (2009), pp. 138–146.

    Google Scholar 

  75. A.A. Al-Munajjed et al., J. Biomed. Mater. Res. B, 90B(2) (2009), pp. 584–591.

    CAS  Google Scholar 

  76. F.G. Lyons et al., Biomaterials, 31(35) (2010), pp. 9232–9243.

    CAS  Google Scholar 

  77. J.P. Gleeson et al., Eur. Cell Mater., 20 (2010), pp. 218–230.

    CAS  Google Scholar 

  78. X. Chen et al., J. Biomed. Eng., 25(5) (2008), pp. 1112–1115.

    CAS  Google Scholar 

  79. C. Zou et al., J. Biomed. Mater. Res. A, 87(1) (2008), pp. 38–44.

    Google Scholar 

  80. G. Cunniffe et al., J. Mater. Sci. Mater. Med., 21(8) (2010), pp. 2293–2298.

    CAS  Google Scholar 

  81. B. Marelli et al., Biomacromolecules, 11(6) (2010), pp. 1470–1479.

    CAS  Google Scholar 

  82. C. Xu et al., Biomaterials, 32(4) (2011), pp. 1051–1058.

    CAS  Google Scholar 

  83. P.V. Giannoudis et al., Injury, 36(3, Supplement 1) (2005), pp. S20–S27.

    Google Scholar 

  84. F. Jegoux et al., Arch. Otolaryngol. Head Neck Surg., 136(10) (2010), pp. 971–978.

    Google Scholar 

  85. J. Xie et al., J. Biomed. Mater. Res. A, 71(1) (2004), pp. 108–117.

    Google Scholar 

  86. J.I. Dawson et al., Biomaterials, 29(21) (2008), pp. 3105–3116.

    CAS  Google Scholar 

  87. G. Wei and P.X. Ma, Biomaterials, 25(19) (2004), pp. 4749–4757.

    CAS  Google Scholar 

  88. S.J. Heo et al., J. Biomed. Mater. Res. A, 89(1) (2009), pp. 108–116.

    Google Scholar 

  89. G.M. Cunniffe et al., J. Biomed. Mater. Res. A, 95(5) (2010), pp. 1142–1149.

    Google Scholar 

  90. C. Curtin et al., Transactions of 2011 Meeting of the Orthopaedic Research Society (Rosemont, IL: Orthopaedic Research Society, 2011), p. 1836.

    Google Scholar 

  91. Y.C. Chai et al., Tissue Eng. Part A, Epub ahead of print (2010).

  92. L. Cheng et al., Acta Biomater., 6(4) (2010), pp. 1569–1574.

    CAS  Google Scholar 

  93. L. Lin et al., J. Biomed. Mater. Res. A, 89(2) (2009), pp. 326–335.

    Google Scholar 

  94. M.C. Meikle, Surgeon, 5(4) (2007), pp. 232–243.

    CAS  Google Scholar 

  95. L. Wang et al., Biomaterials, 31(36) (2010), pp. 9452–9461.

    CAS  Google Scholar 

  96. M.J. Jaasma et al., J. Biotechnol., 133(4) (2008), pp. 490–496.

    CAS  Google Scholar 

  97. C. Jungreuthmayer et al., Tissue Eng. Part A, 15(5) (2009), pp. 1141–1149.

    CAS  Google Scholar 

  98. S. Fuchs et al., Biomaterials, 30(7) (2009), pp. 1329–1338.

    CAS  Google Scholar 

  99. M. Lovett et al., Tissue Eng. Part B Rev., 15(3) (2009), pp. 353–370.

    CAS  Google Scholar 

  100. R.M. Nerem, Tissue Eng., 12(5) (2006), pp. 1143–1150.

    CAS  Google Scholar 

  101. O. Tsigkou et al., Proc. Nat’l. Acad. Sci. USA, 107(8) (2010), pp. 3311–3316.

    CAS  Google Scholar 

  102. G.P. Duffy et al., Eur. Cell Mater. (1) (2001), pp. 15–20.

  103. P. Tayalia and D.J. Mooney, Adv Mater., 21(32–33) (2009), pp. 3269–3285.

    CAS  Google Scholar 

  104. Y.H. Shen et al., Acta Biomater., 4(3) (2008), pp. 477–489.

    CAS  Google Scholar 

  105. M.R. Urist et al., Proc. Nat’l. Acad. Sci. USA, 76(4) (1979), pp. 1828–1832.

    CAS  Google Scholar 

  106. J.M. Wozney and V. Rosen, Clin. Orthop. Relat. Res., 346 (1998), pp. 26–37.

    Google Scholar 

  107. J.H. Jang et al., Mol. Ther., 12(3) (2005), pp. 475–483.

    CAS  Google Scholar 

  108. R.M. Capito and M. Spector, Gene Ther., 14(9) (2007), pp. 721–732.

    CAS  Google Scholar 

  109. X.-D. Sun et al., Biomaterials, 30(6) (2009), pp. 1222–1231.

    CAS  Google Scholar 

  110. M.D. Kofron and C.T. Laurencin, Adv. Drug Deliv. Rev., 58(4) (2006), pp. 555–576.

    CAS  Google Scholar 

  111. M. Lind and C. Bünger, Int. Orthop., 29(4) (2005), pp. 205–209.

    Google Scholar 

  112. J. Bonadio, Adv. Drug Deliv. Rev., 44(2–3) (2000), pp. 185–194.

    CAS  Google Scholar 

  113. J.M. Dang and K.W. Leong, Adv. Drug Deliv. Rev., 58(4) (2006), pp. 487–499.

    CAS  Google Scholar 

  114. J. Bonadio et al., Nat. Med., 5(7) (1999), pp. 753–759.

    CAS  Google Scholar 

  115. J. Fang et al., Proc. Nat’l. Acad. Sci. USA, 93(12) (1996), pp. 5753–5758.

    CAS  Google Scholar 

  116. C. Holladay et al., J. Control Release, 136(3) (2009), pp. 220–225.

    CAS  Google Scholar 

  117. M. Endo et al., Tissue Eng., 12(3) (2006), pp. 489–497.

    CAS  Google Scholar 

  118. N.D. Zinder and J. Lederberg, J. Bacteriol., 64(5) (1952), pp. 679–699.

    CAS  Google Scholar 

  119. C.E. Thomas et al., Nat. Rev. Genet., 4(5) (2003), pp. 346–358.

    CAS  Google Scholar 

  120. R.N. Cohen et al., J. Control Release, 135(2) (2009), pp. 166–174.

    CAS  Google Scholar 

  121. C.E. Pedraza et al., Biomaterials, 29(23) (2008), pp. 3384–3392.

    CAS  Google Scholar 

  122. V. Sokolova and M. Epple, Angewandte Chemie International Edition, 47(8) (2008), pp. 1382–1395.

    CAS  Google Scholar 

  123. C.M. Curtin et al., Transactions of 2011 Meeting of the Orthopaedic Research Society(Rosemont, IL: Orthopaedic Research Society, 2011), p. 293.

    Google Scholar 

  124. E.S. Place et al., Nat. Mater., 8(6) (2009), pp. 457–470.

    CAS  Google Scholar 

  125. L. De Laporte and L.D. Shea, Adv. Drug Deliv. Rev., 59(4–5) (2007), pp. 292–307.

    Google Scholar 

  126. H. Cohen-Sacks et al., J. Control Release, 95(2) (2004), pp. 309–320.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Mechanical and Manufacturing Engineering, Royal College of Surgeons in Ireland, Dublin 2, Ireland

    Gráinne M. Cunniffe

  2. Department of Anatomy, Royal College of Surgeons in Ireland, Dublin 2, Ireland

    Fergal J. O’Brien

  3. Trinity Centre for Bioengineering, Trinity College, Dublin 2, Ireland

    Fergal J. O’Brien

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  1. Gráinne M. Cunniffe
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  2. Fergal J. O’Brien
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Cunniffe, G.M., O’Brien, F.J. Collagen scaffolds for orthopedic regenerative medicine. JOM 63, 66–73 (2011). https://doi.org/10.1007/s11837-011-0061-y

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