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The discovery of secretory IgA and the mucosal immune system

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    SIgA in saliva has been used to monitor the status of the mucosal immune system (reviewed by Albers et al. [12]). The salivary glands (parotid, sublingual, and submandibular) are an important source of SIgA in the upper respiratory tract [13]. Numerous studies of saliva composition have found decreases in salivary SIgA secretion with age [14], psychological and occupational stresses [15–18], nutritional deficiencies [19,20], strenuous physical exercise [21,22], and immune-compromised individuals [23] and may lead to an increased risk of respiratory infections [19,20,24].

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Immunology Yesterday is co-edited by Howard Goodman.

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