Interference With the Renin–Angiotensin System (RAS): Classical Inhibitors and Novel Approaches
References (0)
Cited by (8)
-
Angiotensin-converting enzyme 2 as a potential therapeutic target for COVID-19: A review
2022, Journal of Pharmaceutical AnalysisCitation Excerpt :Recently, much attention has been paid to hrsACE2 (APN01, also known as GSK2586881) [44,45]. Previous studies also suggest that the use of hrsACE2, obtained from the supernatant of ACE2-transfected cells reduced plasma Ang-II and increased plasma Ang (1–7); as a result, it helps to prevent myocardial hypertrophy, fibrosis, and diastolic dysfunction [46]. In other studies, the use of hrsACE2 was safe in healthy human subjects and patients with acute respiratory distress syndrome [47,48].
-
Angiotensin converting enzyme-2 as therapeutic target in COVID-19
2020, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :Since, the ACE2/angiotensin 1-7 axis can be effective in protecting the lung from developing acute respiratory distress syndrome (ARDS) as a main complication of coronaviruses, recently, the recombinant human ACE2 (rhACE2; APN01, GSK2586881) has received a lot of attention [17,18]. With regards to previous studies, administration of rhACE2, which is purified from the supernatant of ACE2 transfected cells, can reduce plasma angiotensin II and increase plasma angiotensin 1–7 and shows the ability to prevent angiotensin II–induced myocardial hypertrophy, diastolic dysfunction, and myocardial fibrosis [19]. Generally, it supposed that excessive ACE2, especially soluble form of ACE2 may slow the virus entering and spreading.
-
COVID-19 infection and recent investigations and future prospects
2023, COVID-19 and Immunomodulation with Special Emphasis on Nutraceutical and Herbal Formulation -
New Insights into the Nephroprotective Potential of Lercanidipine
2023, International Journal of Molecular Sciences -
Containing the spread of COVID-19 virus facing to its high mutation rate: approach to intervention using a nonspecific way of blocking its entry into the cells
2022, Nucleosides, Nucleotides and Nucleic Acids -
SARS-CoV-2 receptor ACE2 and molecular pathway to enter target cells during infection
2022, Reviews and Research in Medical Microbiology