Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1802, Issue 11, November 2010, Pages 995-1005
Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma
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Research Highlights
►TRβ1 mRNA and protein levels are significantly reduced in renal cancer. ►Loss of D1 and reduced level of intracellular T3 are found in kidney tumors. ►TRβ1 decrease in renal cancer is caused by miRNA-204 upregulation. ►5′UTR and 3′UTR are involved in posttranscriptional TRβ1 regulation in renal cancer. ►Renal cancer is characterized by tissue hypothyroidism.
Keywords
Translational control in cancer
Untranslated region
miRNA
Thyroid hormone receptor beta 1
Thyroid hormone
Renal cancer
ccRCC
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