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Nanomechanical Heterogeneity in the Gap and Overlap Regions of Type I Collagen Fibrils with Implications for Bone Heterogeneity

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Department of Mechanical Science and Engineering, University of Illinois at Urbana−Champaign, 1206 West Green Street, Urbana, Illinois 61801
* To whom correspondence should be addressed. Tel.: 01-217-333-9246. Fax: 01-217-333-1942. E-mail: [email protected]
Cite this: Biomacromolecules 2009, 10, 9, 2565–2570
Publication Date (Web):August 20, 2009
https://doi.org/10.1021/bm900519v
Copyright © 2009 American Chemical Society
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    Abstract

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    The microstructure of type I collagen, consisting of alternating gap and overlap regions with a characteristic D period of ∼67 nm, enables multifunctionalities of collagen fibrils in different tissues. Implementing near-surface dynamic and static nanoindentation techniques with atomic force microscope, we reveal mechanical heterogeneity along the axial direction of a single isolated collagen fibril from tendon and show that, within the D period, the gap and overlap regions have significantly different elastic and energy dissipation properties, correlating the significantly different molecular structures in these two regions. We further show that such subfibrillar heterogeneity holds in collagen fibrils inside bone and might be intrinsically related to the excellent energy dissipation performance of bone.

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