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Membrane Assembly Driven by a Biomimetic Coupling Reaction

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† Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, United States
‡ Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States
[email protected]
Cite this: J. Am. Chem. Soc. 2012, 134, 2, 751–753
Publication Date (Web):December 29, 2011
https://doi.org/10.1021/ja2076873
Copyright © 2011 American Chemical Society
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    Abstract

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    One of the major goals of synthetic biology is the development of non-natural cellular systems. In this work, we describe a catalytic biomimetic coupling reaction capable of driving the de novo self-assembly of phospholipid membranes. Our system features a coppercatalyzed azide–alkyne cycloaddition that results in the formation of a triazole-containing phospholipid analogue. Concomitant assembly of membranes occurs spontaneously, not requiring preexisting membranes to house catalysts or precursors. The substitution of efficient synthetic reactions for key biochemical processes may offer a general route toward synthetic biological systems.

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    Experimental details and a Quicktime movie showing tubule formation. This material is available free of charge via the Internet at http://pubs.acs.org.

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