Abstract
FROM a study of a number of crystalline insulins from different animal species, Scott and Fisher1 found that they all had the same microscopic appearance, sulphur content and physiological activity ; and Wasserman and Mirsky2 could find no immunological differences using sensitization and complement fixation experiments. It has thus often been concluded that different insulins are chemically identical, although almost all other proteins have been found to show species differences. The following experiment shows, however, that there are certain definite differences in the detailed chemical structure of insulins from different animal species.
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References
Scott, D. A., and Fisher, A. M., Trans. Roy. Soc. Canada, 34, (V), 137 (1940).
Wasserman, P., and Mirsky, I. A., Endocrin., 31, 115 (1942).
Sanger, F., Biochem. J., 44, 126 (1949).
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Sanger, F. Species Differences in Insulins. Nature 164, 529 (1949). https://doi.org/10.1038/164529a0
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DOI: https://doi.org/10.1038/164529a0
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