Abstract
In this study, 153 Italian centenarians from four different geographical areas, including Modena (northern Italy), Ancona (central Italy), Perugia (central Italy) and Sardinia island (AKEA Project) were enrolled. Plasma levels of vitamin C, uric acid, vitamin A and vitamin E as well as the activities of superoxide dismutase and glutathione peroxidase were measured. Subjects were compared to a younger control population of the same areas, divided into three age groups: ⩽60; 61–80 and 81–99 years. The main result of this study is that, whereas in Italian population elevated levels of plasma vitamins A and E seem to be important for longevity, this do not apply to centenarians from Sardinia, in which probably other factors play a more important role.
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References
Caselli G, Pozzi L, Vaupel JW, Deiana L, Pes G, Carru C et al. (2006). Family clustering in Sardinian longevity: a genealogical approach. Exp Gerontol 41, 727–736.
Deiana L, Ferrucci L, Pes GM, Carru C, Delitala G, Ganau A et al. (1999). AKEntAnnos. The Sardinian Study of extreme longevity. Aging 11, 142–149.
Flohé L, Günzler WA (1984). Assays of glutathione peroxidase. Methods Enzymol 105, 114–121.
Franceschi C, Motta L, Valensin S, Rapisarda R, Franzone A, Berardelli M et al. (2000). Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging 12, 77–84.
Kutnink MA, Hawkes WC, Schaus EE, Omaye ST (1987). An internal standard method for the unattended high-performance liquid analysis of ascorbic acid in blood components. Anal Biochem 166, 424–430.
L’Abbé MR, Fisher PWF (1990). Automated assay of superoxide dismutase in blood. Methods Enzymol 186, 232–237.
Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G et al. (2000). Plasma antioxidants and longevity: a study on healthy centenarians. Free Radical Biol Med 28, 1243–1248.
Meydani M (1999). Dietary antioxidants modulation of aging and immune-endothelial cell interaction. Mech Ageing Dev 111, 123–132.
Nierenberg DW, Nann SL (1992). A method for determining concentrations of retinol, tocopherol, and five carotenoids in human plasma and tissue samples. Am J Clin Nutr 56, 417–426.
Passarino G, Calignano C, Vallone A, Franceschi C, Jeune B, Robine JM et al. (2002). Male/female ratio in centenarians: a possible role played by population genetic structure. Exp Gerontol 37, 1283–1289.
Rattan SI (2004). Aging, anti-aging, and hormesis. Mech Ageing Dev 125, 285–289.
Acknowledgements
LD was funded for the ‘AKEA Project’ by Regione Autonoma della Sardegna, MIUR Italy, the US National Institute on Aging, Duke University no. 03-SC-NIH-1027 (USA), Max-Planck Institute for Demographic Research (MPIDR).
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Contributors: MCP, EM and PM supervised the conduct of the study and drafted the manuscript. MCP and EM did all study assessment. LD and CC obtained the samples. RC and PM analysed study samples. GB, GMP, CF and US were involved in study design and obtaining funding. EM and PM did sample size estimates and the statistical analyses. All contributors reviewed the manuscript.
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Polidori, M., Mariani, E., Baggio, G. et al. Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity. Eur J Clin Nutr 61, 922–924 (2007). https://doi.org/10.1038/sj.ejcn.1602596
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DOI: https://doi.org/10.1038/sj.ejcn.1602596
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