Iron is essential for the survival of both prokaryotic and eukaryotic organisms. It functions as a cofactor for several vital enzymes and iron deprivation is fatal to cells. However, at the same time, excess amounts of iron are also toxic to cells due to the formation of free radicals via the Fenton reaction. As a consequence of its double-edged behaviour, the uptake and regulation of iron involves an intricate balance of acquisition, trafficking, recycling and shuffling between various tissues and organs. This is accomplished by differential regulation of genes involving numerous proteins and enzymes. Several of the proteins identified in these processes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), aconitase and lactoferrin (Lf), possess multiple functions within the cell. Such proteins are referred to as moonlighting or multifunctional proteins, whereby proteins initially thought to possess a single well-established function have subsequently been discovered to exhibit alternative functions. In many cases, these multiple functions are conserved across species.
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December 2014
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Conference Article| November 17 2014
Protein moonlighting in iron metabolism: glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Vishant Mahendra Boradia;
Vishant Mahendra Boradia
*National Institute of Pharmaceutical Education and Research (NIPER), Phase X, Sector 67, SAS Nagar, Punjab 160062, India
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Manoj Raje;
Manoj Raje 1
†Institute of Microbial Technology, Sector 39 A, Chandigarh 160036, India
1Correspondence may be addressed to either of these authors (emailchaaya@niper.ac.in or manoj@imtech.res.in).
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Chaaya Iyengar Raje
Chaaya Iyengar Raje 1
*National Institute of Pharmaceutical Education and Research (NIPER), Phase X, Sector 67, SAS Nagar, Punjab 160062, India
1Correspondence may be addressed to either of these authors (emailchaaya@niper.ac.in or manoj@imtech.res.in).
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Publisher: Portland Press Ltd
Received: August 11 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1796–1801.
Article history
Received:
August 11 2014
Citation
Vishant Mahendra Boradia, Manoj Raje, Chaaya Iyengar Raje; Protein moonlighting in iron metabolism: glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Biochem Soc Trans 1 December 2014; 42 (6): 1796–1801. doi: https://doi.org/10.1042/BST20140220
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