Atomic Coordinates and Structure Factors for Two Helical Configurations of Polypeptide Chains

Is there a formula for a competitive NIH grant application? The Serenity Prayer may provide one: "Grant me the serenity to accept the things I cannot change, the ability to change the things I can, and the wisdom to know the difference." But how to tell ...

Energy invested into reproduction is thought to come at the expense of bodily maintenance. Consistent with this hypothesis, women with higher fertility tend to live shorter, less healthy lives. To test whether costs of reproduction are present ...A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accelerating biological aging. Supporting this prediction are findings that high fertility among women predicts ...

The ready availability of effective antibiotics underpins all of modern medicine. The ever-increasing spread of antimicrobial resistance continuously degrades the efficacy of existing antibiotics, thus requiring the development of innovative ...Here, we describe the identification of an antibiotic class acting via LpxH, a clinically unexploited target in lipopolysaccharide synthesis. The lipopolysaccharide synthesis pathway is essential in most Gram-negative bacteria and there is no analogous ...