Vaginectomy and vaginoplasty for isolated vaginal recurrence 8 years after cervical cancer radical hysterectomy: A case report and literature review

A subgroup of early-stage cervical cancer patients suffer from vaginal cuff recurrence following a primary surgery; however, recurrence after a disease-free interval of 5 years is rare. Treatments for isolated vaginal relapse remain controversial. Here we report a case of a 50-year-old woman with isolated vaginal cuff recurrence 8 years after primary radical surgery for cervical cancer. We conducted a vaginectomy and vaginoplasty using a type of tissue-engineered biomaterial graft. Three chemotherapy cycles of paclitaxel and cisplatin were administered after surgery. The patient has no evidence of disease to date (18 months after surgery) and had regained a satisfactory sexual life by 8 months postoperatively. To our knowledge, this case represents the first report regarding the use of vaginoplasty with biomaterial graft following vaginectomy for late isolated vaginal recurrence of cervical cancer in a patient who had undergone a primary radical hysterectomy.