Intracellular Acidosis Enhances the Excitability of Working Muscle
Abstract
Intracellular acidification of skeletal muscles is commonly thought to contribute to muscle fatigue. However, intracellular acidosis also acts to preserve muscle excitability when muscles become depolarized, which occurs with working muscles. Here, we show that this process may be mediated by decreased chloride permeability, which enables action potentials to still be propagated along the internal network of tubules in a muscle fiber (the T system) despite muscle depolarization. These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue.
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This research was supported by the Danish Medical Research Council(22-02-0188), University of Aarhus, Australian Research Council, and National Health and Medical Research Council of Australia.
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Published In
Science
Volume 305 | Issue 5687
20 August 2004
20 August 2004
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American Association for the Advancement of Science.
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Received: 7 June 2004
Accepted: 27 July 2004
Published in print: 20 August 2004
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- Thomas H. Pedersen et al.
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