Gene Transposition as a Cause of Hybrid Sterility in Drosophila
Abstract
We describe reproductive isolation caused by a gene transposition. In certain Drosophila melanogaster–D. simulans hybrids, hybrid male sterility is caused by the lack of a single-copy gene essential for male fertility, JYAlpha. This gene is located on the fourth chromosome of D. melanogaster but on the third chromosome of D. simulans. Genomic and molecular analyses show that JYAlpha transposed to the third chromosome during the evolutionary history of the D. simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution.
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We thank A. Rasmuson-Lestander and J. Roote for providing fly stocks; M. Saweikis and X. Zhang for technical help; and L. Angerer, R. Angerer, A. Betancourt, J. Bush, A. Clark, J. Coynes, K. Dyer, T. Eickbush, J. Fry, J. Jaenike, N. Phadnis, D. Presgraves, A. Sethi, M. Turelli, and the Evolutionary Genetics Journal Club at UNC for helpful discussion or comments. This work was supported by funds from NSF to C.D.J. and M.A.F.N., from the Canadian Institutes of Health Research to J.L., and from NIH to H.A.O.
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Published In
Science
Volume 313 | Issue 5792
8 September 2006
8 September 2006
Copyright
American Association for the Advancement of Science.
Submission history
Received: 13 April 2006
Accepted: 17 July 2006
Published in print: 8 September 2006
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