Swine as Models in Biomedical Research and Toxicology Testing
Abstract
Breed Selection
Anatomic and Histopathologic Considerations
Cardiovascular System
Lung
Gastrointestinal System
Liver
Pancreas
Kidney and Lower Urinary System
Skin
Reproductive System
Endocrine System
Lymphatic and Hematopoietic Systems
Central Nervous System
Eyes
Musculoskeletal System
Surgical Models and Procedures
Intravascular stents
Vascular aneurysms
Prosthetic valves
Cardiac transplant
Ischemic heart disease (stem cell therapy/gene transfer)
Ventricular assist devices
Digestive system models
Urinary system models
Dermatologic models
Neurologic models
Minipigs as Toxicologic Models in Safety Assessment Studies
Choice of Species
Minipigs in Safety Studies
Safety Pharmacology Studies
Reproductive Studies
Developmental and Juvenile Toxicity Studies
Conclusion
Acknowledgements
Competing Interests
Footnote
References
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Neoplastic transformation of porcine mammary epithelial cells in vitro...
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Effect of propofol and remifentanil on cerebral perfusion and oxygenat...
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A review of the human vs. porcine female genital tract and associated ...
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Establishment of a special pathogen free Chinese Wuzhishan Minipigs Co...
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The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induce...
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Myeloid Leukemias and Virally Induced Lymphomas in Miniature Inbred Sw...
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Age-related Differences in CYP3A Abundance and Activity in the Liver o...
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Temporal plasma vitamin concentrations are altered by fat-soluble vita...
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Botulinum Toxin Type A Induces Changes in the Chemical Coding of Subst...
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Oral Bioavailability, Hydrolysis, and Comparative Toxicokinetics of 3-...
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Micturition in Göttingen minipigs: first reference in vivo data for ur...
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Catheterization of the urethra in female pigs
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Scientific and Regulatory Policy Committee Points-to-consider Paper*...
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Single-dose pharmacokinetics of vancomycin in porcine cancellous and c...
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Blood collection from the orbital sinus of swine
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A pH-responsive supramolecular polymer gel as an enteric elastomer for...
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Quantitative Determination of Tenuazonic Acid in Pig and Broiler Chick...
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Dynamic Distribution of the Gut Microbiota and the Relationship with A...
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Efficacy of the porcine species in biomedical research
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Animal Models for Evaluation of Bone Implants and Devices...
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Preclinical Performance Evaluation of Percutaneous Glucose Biosensors...
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Quantitative determination of fentanyl in newborn pig plasma and cereb...
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Experimental left pneumonectomy in pigs: procedure and management
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Distribution and histopathological changes induced by cysts of ...
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The role of simulation in colon and rectal surgery training
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A porcine model system of BRCA1 driven breast cancer
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Porcine retinal cell line VIDO R1 and Chlamydia suis to modelize ocula...
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Magnetic resonance microimaging of a swine infarcted heart: Performing...
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2,3,3,3‐Tetrafluorpropen [MAK Value Documentation in German Language, ...
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MRS: a noninvasive window into cardiac metabolism
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Template-guided vs. non-guided drilling in site preparation of dental ...
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Considerations on pig models for appetite, metabolic syndrome and obes...
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Selenium deficiency associated porcine and human cardiomyopathies
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Alcohol intake stimulates epithelial proliferation in an authentic mod...
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Experimental Animal Models of Traumatic Coagulopathy
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Anaesthetising pigs
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Role of Toll-like receptors in diabetic renal lesions in a miniature p...
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Regulatory Forum Opinion Piece*...
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3-Methyl-methcathinone: Pharmacokinetic profile evaluation in pigs in ...
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The Feasibility of LigaSure to Create Intestinal Anastomosis...
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A novel method of esophageal lengthening in a large animal model of lo...
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Histomorphometric Analysis of Collagen and Elastic Fibres in the Crani...
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The Histological Components of the Phoniatrical Body-Cover Model in Mi...
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Swine as a Model for Influenza A Virus Infection and Immunity
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Large Animal Models for Vaccine Development and Testing
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Livestock Models in Translational Medicine
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The Influence of Antral Ulcers on Intramural Gastric Nerve Projections...
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Changes in chemical coding of sympathetic chain ganglia (SChG) neurons...
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Characterization of platelet aggregation responses in microminipigs: C...
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Cutaneous wound healing in aging small mammals: a systematic review
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Co-expression of PACAP with VIP, SP and CGRP in the Porcine Nodose Gan...
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Impact of age on hepatic cytochrome P450 of domestic male Camborough‐2...
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Light microscopy and scanning electron microscopy study on microstruct...
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Pulmonary microvascular lesions regress in reperfused chronic thromboe...
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Preclinical evaluation of implantable cardioverter-defibrillator devel...
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Dose-dependent establishment of Trichuris suis larvae in Göttingen min...
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Differences in plasma metabolomics between sows fed dl ...
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Interspecies Differences in Reaction to a Biodegradable Subcutaneous T...
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Spontaneous Background Pathology in Göttingen Minipigs
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Anatomical, Physiological, and Experimental Factors Affecting the Bioa...
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Pattern recognition receptors in the gut: analysis of their expression...
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Comparative genomics reveals tissue-specific regulation of prolactin r...
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The Use of Ice to Enrich the Environment of Pigs Housed Indoors
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Quality Assessment of Domesticated Animal Genome Assemblies
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Animal Models for Cardiac Research
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Bone Tissue Engineering Around Dental Implants
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Biology and Diseases of Swine
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TGFβ2 differentially modulates smooth muscle cell proliferation and mi...
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In vitro models of aortic valve calcification: solidifying a system
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Simultaneous determination of tazarotene and its active metabolite taz...
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Continuous versus Short-Term Infusion of Cefuroxime: Assessment of Con...
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Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evalu...
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Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusi...
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Raised tone reveals ATP as a sympathetic neurotransmitter in the porci...
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Timing of oviductal fluid collection, steroid concentrations, and sper...
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Losartan ameliorates “upstream” pulmonary vein vasculopathy in a pigle...
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Newborn pig trachea cell line cultured in air-liquid interface conditi...
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Genome-wide association studies for hematological traits in Chinese Su...
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MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose...
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The effect of a thermal renal denervation cycle on the mechanical prop...
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A Normative Study of the Synovial Fluid Proteome from Healthy Porcine ...
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Nontraditional Applications in Clinical Pathology
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Prolonged Acetylsalicylic-Acid-Supplementation-Induced Gastritis Affec...
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A new approach to predict human intestinal absorption using porcine in...
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Identification of Niche Conditions Supporting Short-term Culture of Sp...
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Characterization of porcine NLRP3 inflammasome activation and its upst...
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A Novel ECMO Circuit Using a SYNERGY Circulite Pump in a Swine Model
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A Novel Suspension Formulation Enhances Intestinal Absorption of Macro...
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The porcine innate immune system: An update
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Comparative transcriptomic analysis by RNA-seq to discern differential...
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Doppler blood pressure measurement in pigs during anaesthesia
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In Vivo Analytical Performance of Nitric Oxide-Releasing Glucose Biose...
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Experimental Infection of the Pig with Mycobacterium ulcerans: A Novel...
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Chondroitin sulfate and sulfated hyaluronan‐containing collagen coatin...
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Generation of liver-specific TGF-α and c-Myc-overexpressing fibroblast...
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In vivo methods for drug absorption – Comparative physiologies, model ...
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Optical absorption and scattering properties of bulk porcine muscle ph...
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Ontogeny of CYP 3 A ...
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Characterization of a porcine model of post‐operative pain
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Higher body fatness in intrauterine growth retarded juvenile pigs is a...
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Intramural chronotopography of myocardial depolarization in the heart ...
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Genetically engineered pig models for diabetes research
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Intestinal response to myeloablative chemotherapy in piglets
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Extrinsic Primary Afferent Neurons Projecting to the Pylorus in the Do...
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Preclinical QT safety assessment: Cross-species comparisons and human ...
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Usefulness of bovine and porcine IVM/IVF models for reproductive toxic...
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Differential pressure in shunt therapy: investigation of position-depe...
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A review of the toxicology and pathology of the gastrointestinal tract
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Axotomy-Induced Changes in the Chemical Coding Pattern of Colon Projec...
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Intravenous Lipid Emulsion Entraps Amitriptyline into Plasma and Can L...
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Vaccine-Induced Anti-HA2 Antibodies Promote Virus Fusion and Enhance I...
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Animal models for bench to bedside translation of regenerative cardiac...
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Acute Normovolemic Hemodilution in the Pig Is Associated with Renal Ti...
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Assessment of Juvenile Pigs to Serve as Human Pediatric Surrogates for...
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Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swi...
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Determination of coenzyme Q10 tissue status via high-performance liqui...
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Immunohistochemical characterization of the porcine nodose ganglion
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Validation of admittance computed left ventricular volumes against rea...
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Minipigs: Applications in Toxicology
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Best Practices for Performing Experimental Surgery in Swine
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Animal models of toxicology testing: the role of pigs
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Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs C...
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Study Design and Methodologies for Evaluation of Anti-glaucoma Drugs
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The Use of Minipigs in Non-Clinical Research
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Integument
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Performance of conventional pigs and Göttingen miniature pigs in a spa...
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Vagal projections to the pylorus in the domestic pig (Sus scrofa domes...
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Functionalized multiwalled carbon nanotubes as ultrasound contrast age...
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The development of swine models in drug discovery and development
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Your bioanalytical data are only as good as your samples
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Porcine colon explants in the study of innate immune response to Entam...
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The pig: a model for human infectious diseases
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