The Aging Hippocampus: Interactions between Exercise, Depression, and BDNF
Abstract
Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment. However, there is strong evidence that decreased BDNF is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing BDNF by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. Importantly, the most consistent associations between BDNF and hippocampal dysfunction have emerged from research on BDNF protein expression in rodents and serum and plasma concentrations of BDNF in humans. Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood. These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy.
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Article first published online: April 29, 2011
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Anti-depressant-like effects of Jieyu chufan capsules in a mouse model...
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Running-induced Functional Mobility Improvement in the Elderly Males i...
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Association Between Depressive Symptoms and Exercise Capacity in Patie...
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Reduced brain‐derived neurotrophic factor is associated with cognitive...
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Executive function performance and change in aging is predicted by apo...
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The Acute Effects of Aerobic Exercise on the Functional Connectivity o...
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Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Facto...
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Changes in fMRI activation in anterior hippocampus and motor cortex du...
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Aerobic exercise for Alzheimer's disease: A randomized controlled pilo...
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Hippocampal atrophy and memory dysfunction associated with physical in...
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Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depres...
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Effects of Physical Activity on the Cerebral Networks
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Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neuro...
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High-flavonoid intake induces cognitive improvements linked to changes...
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Comorbid Mild Cognitive Impairment and Depressive Symptoms Predict Fut...
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Relationship Between Hippocampal Volume, Serum BDNF, and Depression Se...
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The relationship between brain-derived neurotrophic factor, irisin and...
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G9a-Mediated Regulation of OXT and AVP Expression in the Basolateral A...
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Influence of Aerobic Training and Combinations of Interventions on Cog...
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Exercise-induced neuroprotective effects on neurodegenerative diseases...
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Prefrontal and Hippocampal Brain Volume Deficits: Role of Low Physical...
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Cognitive training with and without additional physical activity in he...
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Lack of an association of BDNF Val66Met polymorphism and plasma BDNF w...
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“I Want a New Drug”: Exercise as a Pharmacological Therapy
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Exercise Regulation of Cognitive Function and Neuroplasticity in the H...
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Plant-derived flavanol (−)epicatechin mitigates anxiety in association...
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Physical Exercise Counteracts Genetic Susceptibility to Depression
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Alzheimer's disease and epigenetic diet
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Lifestyle medicine for depression
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Biological mechanisms underlying the role of physical fitness in healt...
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Depressive symptoms and cognitive performance in older adults
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Neurobiological effects of physical exercise in schizophrenia: a syste...
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Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK...
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Effects of escitalopram on serum BDNF levels in elderly patients with ...
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The BDNF Val66Met polymorphism does not moderate the effect of self-re...
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Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BD...
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Qi Gong to Improve Postural Stability (QTIPS) for Parkinson Fall Preve...
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Aerobic Exercise as an Adjunct Therapy for Improving Cognitive Functio...
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Promoting Neuroplasticity for Motor Rehabilitation After Stroke: Consi...
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Physical activity and the brain: A review of this dynamic, bi-directio...
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Bridging animal and human models of exercise-induced brain plasticity
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The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Moderates ...
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Physical Activity in Depressed Elderly. A Systematic Review
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Activity-dependent, stress-responsive BDNF signaling and the quest for...
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Physical activity and brain plasticity in late adulthood
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