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ENZYME

ENZYME entry: EC 1.1.1.105

Accepted Name
all-trans-retinol dehydrogenase (NAD(+))
Reaction catalysed
all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH
Comment(s)
  • The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
  • No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
  • Also active with 3alpha-hydroxysteroids.
Cross-references
BRENDA 1.1.1.105
EC2PDB 1.1.1.105
ExplorEnz 1.1.1.105
PRIAM enzyme-specific profiles 1.1.1.105
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.105
IUBMB Enzyme Nomenclature 1.1.1.105
IntEnz 1.1.1.105
MEDLINE Find literature relating to 1.1.1.105
MetaCyc 1.1.1.105
Rhea expert-curated reactions 1.1.1.105
UniProtKB/Swiss-Prot
P00325, ADH1B_HUMAN Q5R1W2, ADH1B_PANTR P14139, ADH1B_PAPHA
P08319, ADH4_HUMAN Q9QYY9, ADH4_MOUSE Q64563, ADH4_RAT
P80468, ADH4_STRCA P40394, ADH7_HUMAN Q64437, ADH7_MOUSE
P41682, ADH7_RAT Q7Z5P4, DHB13_HUMAN Q8VCR2, DHB13_MOUSE
Q5M875, DHB13_RAT Q8HYR6, DHRS9_BOVIN Q9BPW9, DHRS9_HUMAN
Q58NB6, DHRS9_MOUSE Q8VD48, DHRS9_RAT Q1RMJ5, DRS7C_BOVIN
A6NNS2, DRS7C_HUMAN Q8CHS7, DRS7C_MOUSE D3ZGP9, DRS7C_RAT
Q3T001, H17B6_BOVIN O14756, H17B6_HUMAN Q9R092, H17B6_MOUSE
O54753, H17B6_RAT O75452, RDH16_HUMAN O54909, RDH16_MOUSE
P50170, RDH16_RAT O88451, RDH7_MOUSE P55006, RDH7_RAT
Q8N3Y7, RDHE2_HUMAN Q7TQA3, RDHE2_MOUSE

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