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ENZYME

ENZYME entry: EC 1.1.1.184

Accepted Name
carbonyl reductase (NADPH)
Alternative Name(s)
aldehyde reductase I
NADPH-dependent carbonyl reductase
prostaglandin 9-ketoreductase
xenobiotic ketone reductase
Reaction catalysed
a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH
Comment(s)
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
Cross-references
BRENDA 1.1.1.184
EC2PDB 1.1.1.184
ExplorEnz 1.1.1.184
PRIAM enzyme-specific profiles 1.1.1.184
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.184
IUBMB Enzyme Nomenclature 1.1.1.184
IntEnz 1.1.1.184
MEDLINE Find literature relating to 1.1.1.184
MetaCyc 1.1.1.184
Rhea expert-curated reactions 1.1.1.184
UniProtKB/Swiss-Prot
P74308, AKR_SYNY3 Q3SZD7, CBR1_BOVIN P16152, CBR1_HUMAN
Q8MI29, CBR1_MACFA P48758, CBR1_MOUSE Q28960, CBR1_PIG
Q5RCU5, CBR1_PONAB P47844, CBR1_RABIT P47727, CBR1_RAT
P08074, CBR2_MOUSE Q29529, CBR2_PIG O75828, CBR3_HUMAN
Q8K354, CBR3_MOUSE B2GV72, CRB3_RAT Q8SPU8, DHRS4_BOVIN
G5EGA6, DHRS4_CAEEL Q9BTZ2, DHRS4_HUMAN Q99LB2, DHRS4_MOUSE
Q8WNV7, DHRS4_PIG Q5RCF8, DHRS4_PONAB Q9GKX2, DHRS4_RABIT
Q8VID1, DHRS4_RAT

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