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ENZYME

ENZYME entry: EC 1.1.1.209

Accepted Name
3(or 17)alpha-hydroxysteroid dehydrogenase
Reaction catalysed
  • androsterone + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH
  • androsterone + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH
Comment(s)
Acts on the 3alpha-hydroxy group of androgens of the 5alpha- androstane series; and also, more slowly, on the 17alpha-hydroxyl group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51).
Cross-references
BRENDA 1.1.1.209
EC2PDB 1.1.1.209
ExplorEnz 1.1.1.209
PRIAM enzyme-specific profiles 1.1.1.209
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.209
IUBMB Enzyme Nomenclature 1.1.1.209
IntEnz 1.1.1.209
MEDLINE Find literature relating to 1.1.1.209
MetaCyc 1.1.1.209
Rhea expert-curated reactions 1.1.1.209
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMAN Q95JH7, AK1C1_MACFA Q95JH6, AK1C1_MACFU
Q5REQ0, AK1C1_PONAB P52895, AK1C2_HUMAN P17516, AK1C4_HUMAN
Q95JH5, AK1C4_MACFA Q95JH4, AK1C4_MACFU Q91WR5, AK1CL_MOUSE
Q6AYQ2, AK1CL_RAT Q8HYR6, DHRS9_BOVIN Q9BPW9, DHRS9_HUMAN
Q58NB6, DHRS9_MOUSE Q8VD48, DHRS9_RAT Q3T001, H17B6_BOVIN
O14756, H17B6_HUMAN Q9R092, H17B6_MOUSE O54753, H17B6_RAT
O75452, RDH16_HUMAN O54909, RDH16_MOUSE P50170, RDH16_RAT
Q27979, RDH5_BOVIN Q92781, RDH5_HUMAN O55240, RDH5_MOUSE

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