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ENZYME

ENZYME entry: EC 1.1.1.236

Accepted Name
tropinone reductase II
Alternative Name(s)
pseudotropine forming tropinone reductase
TR-II
tropinone reductase
Reaction catalysed
NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone
Comment(s)
  • Represents, along with EC 1.1.1.206, a branch point in tropane alkaloid metabolism.
  • Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines.
  • Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific.
Cross-references
BRENDA 1.1.1.236
EC2PDB 1.1.1.236
ExplorEnz 1.1.1.236
PRIAM enzyme-specific profiles 1.1.1.236
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.236
IUBMB Enzyme Nomenclature 1.1.1.236
IntEnz 1.1.1.236
MEDLINE Find literature relating to 1.1.1.236
MetaCyc 1.1.1.236
Rhea expert-curated reactions 1.1.1.236
UniProtKB/Swiss-Prot
A7DY56, TRN1_COCOF P50163, TRN2_DATST P50164, TRN2_HYONI

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