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ENZYME

ENZYME entry: EC 1.1.1.237

Accepted Name
hydroxyphenylpyruvate reductase
Reaction catalysed
  • (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH
  • (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH
  • (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH
  • (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH
Comment(s)
  • The enzyme participates in the biosynthesis of rosmarinic acid.
  • It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
Cross-references
BRENDA 1.1.1.237
EC2PDB 1.1.1.237
ExplorEnz 1.1.1.237
PRIAM enzyme-specific profiles 1.1.1.237
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.237
IUBMB Enzyme Nomenclature 1.1.1.237
IntEnz 1.1.1.237
MEDLINE Find literature relating to 1.1.1.237
MetaCyc 1.1.1.237
Rhea expert-curated reactions 1.1.1.237
UniProtKB/Swiss-Prot
P58409, HCXB_ECO57 P30178, HCXB_ECOLI Q65CJ7, HPPR_PLESU

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