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ENZYME

ENZYME entry: EC 1.1.1.268

Accepted Name
2-(R)-hydroxypropyl-CoM dehydrogenase
Alternative Name(s)
2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase
Reaction catalysed
(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH
Comment(s)
  • Highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, which is highly specific for the (S)-enantiomer.
  • Forms component III of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
Cross-references
BRENDA 1.1.1.268
EC2PDB 1.1.1.268
ExplorEnz 1.1.1.268
PRIAM enzyme-specific profiles 1.1.1.268
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.268
IUBMB Enzyme Nomenclature 1.1.1.268
IntEnz 1.1.1.268
MEDLINE Find literature relating to 1.1.1.268
MetaCyc 1.1.1.268
Rhea expert-curated reactions 1.1.1.268
UniProtKB/Swiss-Prot
Q56840, HCDR1_XANP2

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