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ENZYME

ENZYME entry: EC 1.1.1.270

Accepted Name
3beta-hydroxysteroid 3-dehydrogenase
Alternative Name(s)
3-keto-steroid reductase
3-KSR
Reaction catalysed
a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
Comment(s)
  • The enzyme acts on multiple 3beta-hydroxysteroids.
  • Participates in the biosynthesis of zemosterol and cholesterol, where it catalyzes the reaction in the opposite direction to that shown.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.62.
Cross-references
BRENDA 1.1.1.270
EC2PDB 1.1.1.270
ExplorEnz 1.1.1.270
PRIAM enzyme-specific profiles 1.1.1.270
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.270
IUBMB Enzyme Nomenclature 1.1.1.270
IntEnz 1.1.1.270
MEDLINE Find literature relating to 1.1.1.270
MetaCyc 1.1.1.270
Rhea expert-curated reactions 1.1.1.270
UniProtKB/Swiss-Prot
P14060, 3BHS1_HUMAN P27365, 3BHS1_MACMU Q60555, 3BHS1_MESAU
P24815, 3BHS1_MOUSE P22071, 3BHS1_RAT O35296, 3BHS3_MESAU
Q61767, 3BHS4_MOUSE Q61694, 3BHS5_MOUSE P27364, 3BHS5_RAT
P56937, DHB7_HUMAN O88736, DHB7_MOUSE Q62904, DHB7_RAT
Q3ZBV9, DHR11_BOVIN Q71R50, DHR11_CHICK Q6UWP2, DHR11_HUMAN
Q3U0B3, DHR11_MOUSE Q5A888, ERG27_CANAL Q874K0, ERG27_CANAX
Q6FIV3, ERG27_CANGA Q6BNP0, ERG27_DEBHA Q74ZZ0, ERG27_EREGS
Q6CJC2, ERG27_KLULA O74732, ERG27_SCHPO Q6CE88, ERG27_YARLI
Q12452, ERG27_YEAST Q60A54, SDMB_METCA

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