Expasy logo

ENZYME

ENZYME entry: EC 1.1.1.286

Accepted Name
isocitrate--homoisocitrate dehydrogenase
Alternative Name(s)
homoisocitrate--isocitrate dehydrogenase
Reaction catalysed
  • D-threo-isocitrate + NAD(+) <=> 2-oxoglutarate + CO2 + NADH
  • (2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH
Comment(s)
  • Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrate.
  • May play a role in both the lysine and glutamate biosynthesis pathways.
Cross-references
BRENDA 1.1.1.286
EC2PDB 1.1.1.286
ExplorEnz 1.1.1.286
PRIAM enzyme-specific profiles 1.1.1.286
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.286
IUBMB Enzyme Nomenclature 1.1.1.286
IntEnz 1.1.1.286
MEDLINE Find literature relating to 1.1.1.286
MetaCyc 1.1.1.286
Rhea expert-curated reactions 1.1.1.286
UniProtKB/Swiss-Prot
O59394, HICDH_PYRHO Q72IW9, HICDH_THET2 Q5SIJ1, HICDH_THET8

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-