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ENZYME

ENZYME entry: EC 1.1.1.300

Accepted Name
NADP-retinol dehydrogenase
Alternative Name(s)
all-trans retinal reductase
all-trans-retinol dehydrogenase
NADP(H)-dependent retinol dehydrogenase/reductase
retinol dehydrogenase [NADP(+)]
Reaction catalysed
all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH
Comment(s)
  • Greater catalytic efficiency in the reductive direction.
  • This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63.
  • Km-values for NADP(+) and NADPH are at least 800-fold lower than those for NAD(+) and NADH.
  • This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH.
  • Formerly EC 1.1.1.n2.
Cross-references
BRENDA 1.1.1.300
EC2PDB 1.1.1.300
ExplorEnz 1.1.1.300
PRIAM enzyme-specific profiles 1.1.1.300
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.300
IUBMB Enzyme Nomenclature 1.1.1.300
IntEnz 1.1.1.300
MEDLINE Find literature relating to 1.1.1.300
MetaCyc 1.1.1.300
Rhea expert-curated reactions 1.1.1.300
UniProtKB/Swiss-Prot
O60218, AK1BA_HUMAN C9JRZ8, AK1BF_HUMAN P16116, ALDR_BOVIN
P15121, ALDR_HUMAN P45376, ALDR_MOUSE P80276, ALDR_PIG
P15122, ALDR_RABIT P07943, ALDR_RAT O77769, DHRS3_BOVIN
O75911, DHRS3_HUMAN O88876, DHRS3_MOUSE Q8SPU8, DHRS4_BOVIN
Q99LB2, DHRS4_MOUSE Q8WNV7, DHRS4_PIG Q9GKX2, DHRS4_RABIT
Q8VID1, DHRS4_RAT A1L1W4, RD10A_DANRE Q6DCT3, RD10A_XENLA
Q7T2D1, RD10B_DANRE Q6NRV4, RD10B_XENLA Q8HZT6, RDH10_BOVIN
Q8IZV5, RDH10_HUMAN Q8VCH7, RDH10_MOUSE Q80ZF7, RDH10_RAT
Q5XGF7, RDH10_XENTR Q8TC12, RDH11_HUMAN Q9QYF1, RDH11_MOUSE
P59837, RDH12_BOVIN Q96NR8, RDH12_HUMAN Q8BYK4, RDH12_MOUSE
Q8NBN7, RDH13_HUMAN Q8CEE7, RDH13_MOUSE Q17QW3, RDH14_BOVIN
Q9HBH5, RDH14_HUMAN Q9ERI6, RDH14_MOUSE Q9N126, RDH8_BOVIN
Q9NYR8, RDH8_HUMAN

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