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ENZYME

ENZYME entry: EC 1.1.1.325

Accepted Name
sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
Reaction catalysed
  • L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin
  • L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH
Comment(s)
This enzyme, isolated from the bacterium Chlorobium tepidum, catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC 1.1.1.153.
Cross-references
BRENDA 1.1.1.325
EC2PDB 1.1.1.325
ExplorEnz 1.1.1.325
PRIAM enzyme-specific profiles 1.1.1.325
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.325
IUBMB Enzyme Nomenclature 1.1.1.325
IntEnz 1.1.1.325
MEDLINE Find literature relating to 1.1.1.325
MetaCyc 1.1.1.325
Rhea expert-curated reactions 1.1.1.325
UniProtKB/Swiss-Prot
Q8KES3, SPRE_CHLTE

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