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ENZYME

ENZYME entry: EC 1.1.1.330

Accepted Name
very-long-chain 3-oxoacyl-CoA reductase
Alternative Name(s)
very-long-chain 3-ketoacyl-CoA reductase
very-long-chain beta-ketoacyl-CoA reductase
Reaction catalysed
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
Comment(s)
  • The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.
  • The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.
  • Formerly EC 1.1.1.n13 and EC 2.3.1.119.
Cross-references
BRENDA 1.1.1.330
EC2PDB 1.1.1.330
ExplorEnz 1.1.1.330
PRIAM enzyme-specific profiles 1.1.1.330
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.330
IUBMB Enzyme Nomenclature 1.1.1.330
IntEnz 1.1.1.330
MEDLINE Find literature relating to 1.1.1.330
MetaCyc 1.1.1.330
Rhea expert-curated reactions 1.1.1.330
UniProtKB/Swiss-Prot
Q6P3L6, DH12A_DANRE Q5XG41, DH12A_XENLA Q6QA33, DH12B_DANRE
Q8AVY8, DH12B_XENLA O57314, DHB12_ANAPL Q5E9H7, DHB12_BOVIN
Q53GQ0, DHB12_HUMAN Q4R5G7, DHB12_MACFA O70503, DHB12_MOUSE
Q6P7R8, DHB12_RAT Q28IU1, DHB12_XENTR Q8L9C4, KCR1_ARATH
Q60V51, LE767_CAEBR Q09517, LE767_CAEEL A6RBW9, MKAR_AJECN
A1C6J8, MKAR_ASPCL B0XSI3, MKAR_ASPFC Q4X117, MKAR_ASPFU
A2QCH3, MKAR_ASPNC Q2UET3, MKAR_ASPOR Q0CY11, MKAR_ASPTN
A6SG70, MKAR_BOTFB Q59V93, MKAR_CANAL Q6FRM0, MKAR_CANGA
Q2H1V7, MKAR_CHAGB Q1DNC5, MKAR_COCIM A8N6B4, MKAR_COPC7
P0CR35, MKAR_CRYNB P0CR34, MKAR_CRYNJ Q6BIG0, MKAR_DEBHA
Q5B0R9, MKAR_EMENI Q75A60, MKAR_EREGS Q6CVS4, MKAR_KLULA
B0D8R3, MKAR_LACBS A5E0R1, MKAR_LODEL A8Q1U2, MKAR_MALGO
A1DH66, MKAR_NEOFI Q7RYE5, MKAR_NEUCR Q0U3N7, MKAR_PHANO
A5DND6, MKAR_PICGU A3LXZ3, MKAR_PICST B2B3L4, MKAR_PODAN
A4QTE3, MKAR_PYRO7 B2WMJ3, MKAR_PYRTR Q10245, MKAR_SCHPO
A7F8T1, MKAR_SCLS1 Q4P622, MKAR_USTMA A7TMJ2, MKAR_VANPO
Q6CHP1, MKAR_YARLI B3LN00, MKAR_YEAS1 A6ZLA1, MKAR_YEAS7
P38286, MKAR_YEAST

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