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ENZYME

ENZYME entry: EC 1.1.1.337

Accepted Name
L-2-hydroxycarboxylate dehydrogenase (NAD(+))
Alternative Name(s)
(R)-sulfolactate dehydrogenase
L-2-hydroxyacid dehydrogenase (NAD(+))
L-sulfolactate dehydrogenase
Reaction catalysed
a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH
Comment(s)
  • The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple L-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)- malate, (S)-lactate, and (S)-2-hydroxyglutarate.
  • Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
Cross-references
BRENDA 1.1.1.337
EC2PDB 1.1.1.337
ExplorEnz 1.1.1.337
PRIAM enzyme-specific profiles 1.1.1.337
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.337
IUBMB Enzyme Nomenclature 1.1.1.337
IntEnz 1.1.1.337
MEDLINE Find literature relating to 1.1.1.337
MetaCyc 1.1.1.337
Rhea expert-curated reactions 1.1.1.337
UniProtKB/Swiss-Prot
Q58820, COMC_METJA O27273, COMC_METTH

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