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ENZYME

ENZYME entry: EC 1.1.1.62

Accepted Name
17beta-estradiol 17-dehydrogenase
Alternative Name(s)
17beta-estradiol dehydrogenase
17beta-HSD
17beta-hydroxysteroid dehydrogenase
20alpha-hydroxysteroid dehydrogenase
estrogen 17-oxidoreductase
Reaction catalysed
  • 17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH
  • 17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH
Comment(s)
  • The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
Cross-references
BRENDA 1.1.1.62
EC2PDB 1.1.1.62
ExplorEnz 1.1.1.62
PRIAM enzyme-specific profiles 1.1.1.62
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.62
IUBMB Enzyme Nomenclature 1.1.1.62
IntEnz 1.1.1.62
MEDLINE Find literature relating to 1.1.1.62
MetaCyc 1.1.1.62
Rhea expert-curated reactions 1.1.1.62
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMAN Q95JH7, AK1C1_MACFA Q95JH6, AK1C1_MACFU
Q5REQ0, AK1C1_PONAB P52895, AK1C2_HUMAN P42330, AK1C3_HUMAN
Q5R7C9, AK1C3_PONAB P17516, AK1C4_HUMAN Q95JH5, AK1C4_MACFA
Q95JH4, AK1C4_MACFU Q6P3L6, DH12A_DANRE Q5XG41, DH12A_XENLA
Q6QA33, DH12B_DANRE Q8AVY8, DH12B_XENLA Q8NBQ5, DHB11_HUMAN
Q4JK73, DHB11_MACFA Q9EQ06, DHB11_MOUSE Q5NVG2, DHB11_PONAB
Q6AYS8, DHB11_RAT O57314, DHB12_ANAPL Q5E9H7, DHB12_BOVIN
Q53GQ0, DHB12_HUMAN Q4R5G7, DHB12_MACFA O70503, DHB12_MOUSE
Q6P7R8, DHB12_RAT Q28IU1, DHB12_XENTR Q7Z5P4, DHB13_HUMAN
Q8VCR2, DHB13_MOUSE Q5M875, DHB13_RAT Q9MYP6, DHB14_BOVIN
Q9BPX1, DHB14_HUMAN P14061, DHB1_HUMAN P51656, DHB1_MOUSE
Q1WNP0, DHB1_PANTR P51657, DHB1_RAT P37059, DHB2_HUMAN
P51658, DHB2_MOUSE Q62730, DHB2_RAT P37058, DHB3_HUMAN
P70385, DHB3_MOUSE O54939, DHB3_RAT P56937, DHB7_HUMAN
O88736, DHB7_MOUSE Q62904, DHB7_RAT Q9GME3, DHB8_CALJA
Q5TJF5, DHB8_CANLF Q92506, DHB8_HUMAN P50171, DHB8_MOUSE
Q9XT00, DHB8_PIG Q6MGB5, DHB8_RAT Q3ZBV9, DHR11_BOVIN
Q71R50, DHR11_CHICK Q6UWP2, DHR11_HUMAN Q3U0B3, DHR11_MOUSE
Q3T001, H17B6_BOVIN O14756, H17B6_HUMAN Q9R092, H17B6_MOUSE
O54753, H17B6_RAT O02691, HCD2_BOVIN O18404, HCD2_DROME
Q99714, HCD2_HUMAN O08756, HCD2_MOUSE O70351, HCD2_RAT
Q93W57, HSDA_SESIN Q8LKV5, HSDB_SESIN A0A140FAN3, HSD_PINMS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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