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ENZYME

ENZYME entry: EC 1.1.1.87

Accepted Name
homoisocitrate dehydrogenase
Alternative Name(s)
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating)
2-hydroxy-3-carboxyadipate dehydrogenase
3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating)
3-carboxy-2-hydroxyadipate dehydrogenase
homoisocitric dehydrogenase
Reaction catalysed
(2R,3S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH
Comment(s)
  • Forms part of the lysine biosynthesis pathway in fungi.
  • Formerly EC 1.1.1.155.
Cross-references
BRENDA 1.1.1.87
EC2PDB 1.1.1.87
ExplorEnz 1.1.1.87
PRIAM enzyme-specific profiles 1.1.1.87
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.87
IUBMB Enzyme Nomenclature 1.1.1.87
IntEnz 1.1.1.87
MEDLINE Find literature relating to 1.1.1.87
MetaCyc 1.1.1.87
Rhea expert-curated reactions 1.1.1.87
UniProtKB/Swiss-Prot
Q58991, AKSF_METJA O14104, LYS12_SCHPO P40495, LYS12_YEAST

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