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ENZYME

ENZYME entry: EC 1.1.1.95

Accepted Name
phosphoglycerate dehydrogenase
Alternative Name(s)
3-phosphoglycerate dehydrogenase
3-phosphoglyceric acid dehydrogenase
3PHP reductase
alphaKG reductase
alpha-phosphoglycerate dehydrogenase
D-3-phosphoglycerate dehydrogenase
glycerate-1,3-phosphate dehydrogenase
glycerate 3-phosphate dehydrogenase
PGDH
phosphoglycerate oxidoreductase
phosphoglyceric acid dehydrogenase
Reaction catalysed
(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH
Comment(s)
  • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
  • The reaction occurs predominantly in the direction of reduction.
  • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
Cross-references
BRENDA 1.1.1.95
EC2PDB 1.1.1.95
ExplorEnz 1.1.1.95
PRIAM enzyme-specific profiles 1.1.1.95
KEGG Ligand Database for Enzyme Nomenclature 1.1.1.95
IUBMB Enzyme Nomenclature 1.1.1.95
IntEnz 1.1.1.95
MEDLINE Find literature relating to 1.1.1.95
MetaCyc 1.1.1.95
Rhea expert-curated reactions 1.1.1.95
UniProtKB/Swiss-Prot
P40510, SER33_YEAST O49485, SERA1_ARATH O04130, SERA2_ARATH
Q9LT69, SERA3_ARATH O29445, SERA_ARCFU P35136, SERA_BACSU
Q5EAD2, SERA_BOVIN Q54UH8, SERA_DICDI P0A9T2, SERA_ECO57
P0A9T1, SERA_ECOL6 P0A9T0, SERA_ECOLI P43885, SERA_HAEIN
O43175, SERA_HUMAN Q60HD7, SERA_MACFA Q58424, SERA_METJA
O27051, SERA_METTH Q61753, SERA_MOUSE P0A545, SERA_MYCBO
O33116, SERA_MYCLE P9WNX2, SERA_MYCTO P9WNX3, SERA_MYCTU
A5A6P1, SERA_PANTR A5GFY8, SERA_PIG Q5R7M2, SERA_PONAB
O08651, SERA_RAT P87228, SERA_SCHPO P0A9T3, SERA_SHIFL
P73821, SERA_SYNY3 P40054, SERA_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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