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ENZYME

ENZYME entry: EC 1.1.5.3

Accepted Name
glycerol-3-phosphate dehydrogenase
Alternative Name(s)
FAD-dependent glycerol-3-phosphate dehydrogenase
flavin-linked glycerol-3-phosphate dehydrogenase
glycerol-3-phosphate CoQ reductase
glycerophosphate dehydrogenase
L-glycerophosphate dehydrogenase
sn-glycerol-3-phosphate dehydrogenase
Reaction catalysed
a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate
Comment(s)
  • An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.
  • In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.
  • In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.
  • This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.
  • Insect flight muscle uses only CoQ10 as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ9.
  • The enzyme is activated by calcium.
  • Formerly EC 1.1.2.1 and EC 1.1.99.5.
Cross-references
BRENDA 1.1.5.3
EC2PDB 1.1.5.3
ExplorEnz 1.1.5.3
PRIAM enzyme-specific profiles 1.1.5.3
KEGG Ligand Database for Enzyme Nomenclature 1.1.5.3
IUBMB Enzyme Nomenclature 1.1.5.3
IntEnz 1.1.5.3
MEDLINE Find literature relating to 1.1.5.3
MetaCyc 1.1.5.3
Rhea expert-curated reactions 1.1.5.3
UniProtKB/Swiss-Prot
D4GYI2, GLPA1_HALVD D4GQU6, GLPA2_HALVD P0A9C1, GLPA_ECO57
P0A9C0, GLPA_ECOLI P43799, GLPA_HAEIN P0A9C2, GLPA_SHIFL
A3MZ98, GLPB_ACTP2 B3H0P4, GLPB_ACTP7 B0BTN3, GLPB_ACTPJ
A6VKT7, GLPB_ACTSZ Q5E0X7, GLPB_ALIF1 B5ET22, GLPB_ALIFM
A8ADX8, GLPB_CITK8 A7ZP63, GLPB_ECO24 B7UFQ3, GLPB_ECO27
B7MG07, GLPB_ECO45 B7LAR0, GLPB_ECO55 Q8XE13, GLPB_ECO57
B5YX30, GLPB_ECO5E B7NN59, GLPB_ECO7I B7MXS2, GLPB_ECO81
B7M5S7, GLPB_ECO8A C4ZU83, GLPB_ECOBW B1X8D6, GLPB_ECODH
A8A2A7, GLPB_ECOHS A1AD94, GLPB_ECOK1 Q0TFK1, GLPB_ECOL5
Q8FFN4, GLPB_ECOL6 B1IXU6, GLPB_ECOLC P13033, GLPB_ECOLI
B7N5K6, GLPB_ECOLU B6I7H1, GLPB_ECOSE B1LLJ4, GLPB_ECOSM
Q1R9H5, GLPB_ECOUT A4WCP1, GLPB_ENT38 B7LM86, GLPB_ESCF3
B8F6F3, GLPB_GLAP5 Q7VM49, GLPB_HAEDU Q4QMN2, GLPB_HAEI8
A5UE48, GLPB_HAEIE A5UHH2, GLPB_HAEIG P43800, GLPB_HAEIN
B0R6S4, GLPB_HALS3 Q9HNS3, GLPB_HALSA Q0I239, GLPB_HISS1
B0UVX7, GLPB_HISS2 B5XNY5, GLPB_KLEP3 A6TBU4, GLPB_KLEP7
Q65R09, GLPB_MANSM Q9CL07, GLPB_PASMU Q6CZI7, GLPB_PECAS
C6DH98, GLPB_PECCP Q6LSE4, GLPB_PHOPR B5EYX0, GLPB_SALA4
A9MJD3, GLPB_SALAR Q57M68, GLPB_SALCH B5FNS6, GLPB_SALDC
B5R258, GLPB_SALEP B5RCB0, GLPB_SALG2 B4TBF2, GLPB_SALHS
B4SYV7, GLPB_SALNS Q5PI45, GLPB_SALPA A9N5C9, GLPB_SALPB
B5BCR1, GLPB_SALPK B4TPG8, GLPB_SALSV Q8Z553, GLPB_SALTI
Q8ZNG4, GLPB_SALTY B2TW33, GLPB_SHIB3 Q31Z75, GLPB_SHIBS
Q32DU5, GLPB_SHIDS Q0T2N9, GLPB_SHIF8 Q83ML0, GLPB_SHIFL
Q3YZW4, GLPB_SHISS A5EZR7, GLPB_VIBC3 Q9KLJ6, GLPB_VIBCH
C3LW14, GLPB_VIBCM Q8D7Y4, GLPB_VIBVU Q7MF00, GLPB_VIBVY
A1JIB0, GLPB_YERE8 Q1CBK6, GLPB_YERPA Q8ZAH6, GLPB_YERPE
Q1CNF8, GLPB_YERPN Q66FX5, GLPB_YERPS P64183, GLPD1_MYCBO
P9WN80, GLPD1_MYCTO P9WN81, GLPD1_MYCTU P64185, GLPD2_MYCBO
P9WN78, GLPD2_MYCTO P9WN79, GLPD2_MYCTU P18158, GLPD_BACSU
P13035, GLPD_ECOLI P53435, GLPD_MYCLE P52111, GLPD_PSEAE
O83004, GLPD_PSETO Q2FHD8, GLPD_STAA3 Q2FYZ4, GLPD_STAA8
Q2YXR5, GLPD_STAAB Q5HGD1, GLPD_STAAC Q99UH2, GLPD_STAAM
Q7A5V7, GLPD_STAAN Q6GHD4, GLPD_STAAR Q6G9R2, GLPD_STAAS
Q7A105, GLPD_STAAW Q5HPP0, GLPD_STAEQ Q8CPE6, GLPD_STAES
Q4L608, GLPD_STAHJ Q49X94, GLPD_STAS1 P74257, GLPD_SYNY3
Q8SR40, GPDH_ENCCU A6QLU1, GPDM_BOVIN P90795, GPDM_CAEEL
Q54QC1, GPDM_DICDI P43304, GPDM_HUMAN Q4R755, GPDM_MACFA
A7DZP8, GPDM_MESAU Q64521, GPDM_MOUSE P35571, GPDM_RAT
O14400, GPDM_SCHPO P32191, GPDM_YEAST Q9SS48, SDP6_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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