Accepted Name |
chloride peroxidase |
Alternative Name(s) |
chloroperoxidase |
CPO |
vanadium haloperoxidase |
Reaction catalysed |
RH + Cl(-) + H2O2 <=> RCl + 2 H2O |
Comment(s) |
- Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds.
- Also oxidizes bromide and iodide.
- Enzymes of this type are either heme-thiolate proteins, or contain vanadate.
- A secreted enzyme produced by the ascomycetous fungus Caldariomyces fumago (Leptoxyphium fumago) is an example of the heme-thiolate type.
- It catalyzes the production of hypochlorous acid by transferring one oxygen atom from H2O2 to chloride.
- At a separate site it catalyzes the chlorination of activated aliphatic and aromatic substrates, via HClO and derived chlorine species.
- In the absence of halides, it shows peroxidase (e.g. phenol oxidation) and peroxygenase activities.
- The latter inserts oxygen from H2O2 into, for example, styrene (side chain epoxidation) and toluene (benzylic hydroxylation), however, these activities are less pronounced than its activity with halides.
- Has little activity with non-activated substrates such as aromatic rings, ethers or saturated alkanes.
- The chlorinating peroxidase produced by ascomycetous fungi (e.g. Curvularia inaequalis) is an example of a vanadium chloroperoxidase, and is related to bromide peroxidase (EC 1.11.1.18).
- It contains vanadate and oxidizes chloride, bromide and iodide into hypohalous acids.
- In the absence of halides, it peroxygenates organic sulfides and oxidizes ABTS [2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid)] but no phenols.
|
Cross-references |
BRENDA |
1.11.1.10 |
EC2PDB |
1.11.1.10 |
ExplorEnz |
1.11.1.10 |
PRIAM enzyme-specific profiles |
1.11.1.10 |
KEGG Ligand Database for Enzyme Nomenclature |
1.11.1.10 |
IUBMB Enzyme Nomenclature |
1.11.1.10 |
IntEnz |
1.11.1.10 |
MEDLINE |
Find literature relating to 1.11.1.10 |
MetaCyc |
1.11.1.10 |
Rhea expert-curated reactions |
1.11.1.10 |
UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-