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ENZYME

ENZYME entry: EC 1.11.1.20

Accepted Name
prostamide/prostaglandin F2alpha synthase
Alternative Name(s)
prostamide/PGF synthase
prostamide/prostaglandin F synthase
prostamide F synthase
TPGF synthase
Reaction catalysed
[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha
Comment(s)
  • The enzyme contains a thioredoxin-type disulfide as a catalytic group.
  • Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2alpha.
  • The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
Cross-references
BRENDA 1.11.1.20
EC2PDB 1.11.1.20
ExplorEnz 1.11.1.20
PRIAM enzyme-specific profiles 1.11.1.20
KEGG Ligand Database for Enzyme Nomenclature 1.11.1.20
IUBMB Enzyme Nomenclature 1.11.1.20
IntEnz 1.11.1.20
MEDLINE Find literature relating to 1.11.1.20
MetaCyc 1.11.1.20
Rhea expert-curated reactions 1.11.1.20
UniProtKB/Swiss-Prot
C1C416, PXL2B_AQUCT Q58CY6, PXL2B_BOVIN Q6NV24, PXL2B_DANRE
Q8TBF2, PXL2B_HUMAN Q9DB60, PXL2B_MOUSE A9CQL8, PXL2B_PIG
Q5R7S9, PXL2B_PONAB D3ZVR7, PXL2B_RAT B5X9L9, PXL2B_SALSA
Q6AZG8, PXL2B_XENLA Q28IJ3, PXL2B_XENTR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.11.-.-
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