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ENZYME

ENZYME entry: EC 1.11.2.4

Accepted Name
fatty-acid peroxygenase
Alternative Name(s)
CYP152A1
fatty acid hydroxylase
P450 peroxygenase
P450SPalpha
Reaction catalysed
  • a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O
  • a 2,3-saturated fatty acid + H2O2 <=> a 3-hydroxy fatty acid + H2O
Comment(s)
  • A cytosolic heme-thiolate protein with sequence homology to P450 monooxygenases.
  • Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function.
  • Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis).
  • Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalyzed by the common P450s.
  • A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated.
  • Oxidizes the peroxidase substrate 3,3,5,5-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.
Cross-references
BRENDA 1.11.2.4
EC2PDB 1.11.2.4
ExplorEnz 1.11.2.4
PRIAM enzyme-specific profiles 1.11.2.4
KEGG Ligand Database for Enzyme Nomenclature 1.11.2.4
IUBMB Enzyme Nomenclature 1.11.2.4
IntEnz 1.11.2.4
MEDLINE Find literature relating to 1.11.2.4
MetaCyc 1.11.2.4
Rhea expert-curated reactions 1.11.2.4
UniProtKB/Swiss-Prot
I3DZK9, CYPC_BACMM O31440, CYPC_BACSU

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