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ENZYME

ENZYME entry: EC 1.14.14.1

Accepted Name
unspecific monooxygenase
Alternative Name(s)
aryl-4-monooxygenase
aryl hydrocarbon hydroxylase
cytochrome P450
flavoprotein-linked monooxygenase
microsomal monooxygenase
microsomal P450
xenobiotic monooxygenase
Reaction catalysed
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
Cross-references
BRENDA 1.14.14.1
EC2PDB 1.14.14.1
ExplorEnz 1.14.14.1
PRIAM enzyme-specific profiles 1.14.14.1
KEGG Ligand Database for Enzyme Nomenclature 1.14.14.1
IUBMB Enzyme Nomenclature 1.14.14.1
IntEnz 1.14.14.1
MEDLINE Find literature relating to 1.14.14.1
MetaCyc 1.14.14.1
Rhea expert-curated reactions 1.14.14.1
UniProtKB/Swiss-Prot
A0A3G9HRC2, ALT2_ALTAL Q81BF4, C102_BACCR Q9PVE8, C330_FUNHE
Q98T91, C340_ORYLA Q8AXY5, C356_FUNHE Q2UNA2, C505_ASPOR
Q9Y8G7, C505_FUSOX O23066, C86A2_ARATH Q9LMM1, C86A4_ARATH
Q9CAD6, C86A7_ARATH O80823, C86A8_ARATH Q3LFU0, CP1A1_BALAC
P56590, CP1A1_CANLF Q06367, CP1A1_CAVPO Q92039, CP1A1_CHACA
O42231, CP1A1_CHEAU Q9W683, CP1A1_CHESA P79716, CP1A1_DICLA
Q5KQT7, CP1A1_FELCA P04798, CP1A1_HUMAN O42430, CP1A1_LIMLI
P33616, CP1A1_MACFA Q6GUR1, CP1A1_MACMU Q00557, CP1A1_MESAU
Q92148, CP1A1_MICTO P00184, CP1A1_MOUSE Q92110, CP1A1_ONCMY
Q92095, CP1A1_OPSTA Q6JZS3, CP1A1_ORYLA P98181, CP1A1_PAGMA
Q9YH64, CP1A1_PLAFE Q92100, CP1A1_PLEPL P05176, CP1A1_RABIT
P00185, CP1A1_RAT P56591, CP1A1_SHEEP O42457, CP1A1_SPAAU
Q92116, CP1A1_STECH Q3LFT9, CP1A2_BALAC O77810, CP1A2_CALJA
P56592, CP1A2_CANLF Q64391, CP1A2_CAVPO Q01741, CP1A2_CHICK
Q5KQT6, CP1A2_FELCA P05177, CP1A2_HUMAN O77809, CP1A2_MACFA
Q4H4C3, CP1A2_MACFU P24453, CP1A2_MESAU P00186, CP1A2_MOUSE
Q5RBQ1, CP1A2_PONAB P00187, CP1A2_RABIT P04799, CP1A2_RAT
Q92109, CP1A3_ONCMY P79760, CP1A4_CHICK P79761, CP1A5_CHICK
Q16678, CP1B1_HUMAN Q64429, CP1B1_MOUSE Q64678, CP1B1_RAT
P56654, CP237_MOUSE P56655, CP238_MOUSE P56656, CP239_MOUSE
O62671, CP241_CANLF P79402, CP242_PIG Q6XVG2, CP254_MOUSE
Q9D816, CP255_MOUSE P33273, CP255_RAT Q6V0L0, CP26C_HUMAN
B2RXA7, CP26C_MOUSE P11711, CP2A1_RAT P15149, CP2A2_RAT
P20812, CP2A3_RAT P15392, CP2A4_MOUSE P20852, CP2A5_MOUSE
P20853, CP2A7_HUMAN P80055, CP2A7_PAPSP P24454, CP2A8_MESAU
P24455, CP2A9_MESAU Q05555, CP2AA_RABIT Q05556, CP2AB_RABIT
P56593, CP2AC_MOUSE Q16696, CP2AD_HUMAN P22779, CP2AX_BOVIN
P00176, CP2B1_RAT P04167, CP2B2_RAT P13107, CP2B3_RAT
P00178, CP2B4_RABIT P12789, CP2B5_RABIT P12790, CP2B9_MOUSE
P12791, CP2BA_MOUSE P24460, CP2BB_CANLF P33272, CP2BC_RAT
Q64583, CP2BF_RAT O55071, CP2BJ_MOUSE P34033, CP2BX_CAVPO
P00180, CP2C1_RABIT P00181, CP2C2_RABIT P00182, CP2C3_RABIT
P11371, CP2C4_RABIT P00179, CP2C5_RABIT P05178, CP2C6_RAT
P05179, CP2C7_RAT P10632, CP2C8_HUMAN P11712, CP2C9_HUMAN
P08683, CP2CB_RAT P11510, CP2CC_RAT P20814, CP2CD_RAT
P17666, CP2CE_RABIT P11372, CP2CF_RABIT P15123, CP2CG_RABIT
P33260, CP2CI_HUMAN P33261, CP2CJ_HUMAN P33262, CP2CK_MACFA
P56594, CP2CL_CANLF Q08078, CP2CP_MESAU P33263, CP2CQ_MESAU
P33264, CP2CR_MESAU P33265, CP2CS_MESAU Q64458, CP2CT_MOUSE
Q29510, CP2CU_RABIT Q29478, CP2CV_CAPHE P10633, CP2D1_RAT
P12938, CP2D3_RAT Q64680, CP2D4_RAT A0A087X1C5, CP2D7_HUMAN
P11714, CP2D9_MOUSE P24456, CP2DA_MOUSE P12939, CP2DA_RAT
P24457, CP2DB_MOUSE Q01361, CP2DE_BOVIN Q29473, CP2DF_CANLF
Q64403, CP2DG_CAVPO Q29488, CP2DH_MACFA O18992, CP2DJ_CALJA
Q8CIM7, CP2DQ_MOUSE P10634, CP2DQ_RAT O18963, CP2E1_BOVIN
Q9MZY0, CP2E1_CANLF P05181, CP2E1_HUMAN P33266, CP2E1_MACFA
Q6GUQ4, CP2E1_MACMU P51581, CP2E1_MESAU Q05421, CP2E1_MOUSE
P79383, CP2E1_PIG P08682, CP2E1_RABIT P05182, CP2E1_RAT
P24903, CP2F1_HUMAN O18809, CP2F3_CAPHI Q8WNE1, CP2F5_GORGO
P24461, CP2G1_RABIT P10610, CP2G1_RAT P05180, CP2H1_CHICK
P20678, CP2H2_CHICK P52786, CP2J1_RABIT P51590, CP2J3_RAT
Q9QXF7, CP2J4_RAT O54749, CP2J5_MOUSE O54750, CP2J6_MOUSE
Q92090, CP2K1_ONCMY O93299, CP2K3_ONCMY O93297, CP2K4_ONCMY
Q27712, CP2L1_PANAR Q92088, CP2M1_ONCMY Q9JMA7, CP341_MOUSE
Q9HB55, CP343_HUMAN P04800, CP3A1_RAT P05183, CP3A2_RAT
P08684, CP3A4_HUMAN P20815, CP3A5_HUMAN P80056, CP3A5_PAPSP
P11707, CP3A6_RABIT P24462, CP3A7_HUMAN P33268, CP3A8_MACFA
P51538, CP3A9_RAT Q64459, CP3AB_MOUSE P24463, CP3AC_CANLF
Q64464, CP3AD_MOUSE Q64417, CP3AE_CAVPO Q64406, CP3AF_CAVPO
Q64481, CP3AG_MOUSE Q64409, CP3AH_CAVPO Q64581, CP3AI_RAT
P79152, CP3AJ_CAPHE O18993, CP3AL_CALJA Q29496, CP3AO_SHEEP
O09158, CP3AP_MOUSE O42563, CP3AR_ONCMY P79102, CP3AS_BOVIN
P79401, CP3AT_PIG O70537, CP3AV_MESAU P10611, CP4A4_RABIT
Q02928, CP4AB_HUMAN P24464, CP4AC_RAT P13584, CP4B1_HUMAN
Q64462, CP4B1_MOUSE P15128, CP4B1_RABIT P15129, CP4B1_RAT
P29981, CP4C1_BLADI Q91WL5, CP4CA_MOUSE A2A974, CP4CB_MOUSE
Q964T1, CP4CU_BLAGE P78329, CP4F2_HUMAN Q08477, CP4F3_HUMAN
P51870, CP4F5_RAT P51871, CP4F6_RAT P98187, CP4F8_HUMAN
Q9HBI6, CP4FB_HUMAN Q9HCS2, CP4FC_HUMAN Q86W10, CP4Z1_HUMAN
P13527, CP6A1_MUSDO Q04552, CP6B1_PAPPO Q27664, CP6B2_HELAM
Q27756, CP6B3_PAPPO Q27902, CP6B4_PAPGL Q95036, CP6B5_PAPGL
Q95031, CP6B6_HELAM O61387, CP6B7_HELAM P14779, CPXB_PRIM2
Q91X77, CY250_MOUSE A0A0C3HJL3, CYAG1_OIDMZ O08336, CYPB_BACSU
I7ZK32, CYPC3_ASPO3 G5EJN7, CYPD6_PHACH O08394, CYPD_BACSU
A2QLV1, CYPE1_ASPNC Q0D1W9, CYPE3_ASPTN A0A0G4P2K0, CYPE4_PENC3
A0A0A2J1Z6, CYPE4_PENEN A0A101MN42, CYPE4_PENFR G7XMT1, CYPE5_ASPKW
A0A100IM63, CYPE5_ASPNG G9MLG2, CYPP1_HYPVG R0IGL9, CYPU2_EXST2
Q9HGE0, FUM6_GIBM7

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
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